06/19/2026
"The main mechanism through which patients with multiple sclerosis (MS) acquire disability is progression independent of relapse activity (PIRA).1-3 The pathogenic processes underlying PIRA are strongly associated with chronic inflammation and neurodegeneration.4,5 However, PIRA events may also be preceded by acute inflammatory activity, as indicated by the presence of new or enlarging T2 lesions on MRI in up to 50% of cases.3 Preventing PIRA from occurring in the first place—by targeting the processes that ultimately drive it—therefore appears crucial for limiting long-term disability."
Find out more about "High-efficacy therapy and progression independent of relapse and MRI activity in multiple sclerosis."
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This scientific commentary refers to ‘Progression independent of relapse and MRI activity and treatment strategies in multiple sclerosis’ by Rollot et al.