02/03/2021
Not a day has gone by in 6 years without the power of Nrf2 activation charging up my cellular batteries 🙌🏽😊. Im very blessed indeed🌹‼️ Read why:
The Sun UK headline-Dec2016:
HOPE ON DEMENTIA
A SINGLE protein could “cure” Alzheimer’s and Parkinson’s, a new study found.
A new study by the Gladstone Institutes in San Francisco, CA used a different protein, 💥💥Nrf2,💥💥 to restore levels of the disease-causing proteins to a normal, healthy range and stop cell death.
Controlling levels of the protein could lead to new treatments for degenerative brain diseases such as Huntington’s.
Professor Dr Steven Finkbeiner, a senior investigator and author, said: “I am very enthusiastic about this strategy for treating neurodegenerative diseases. We’ve tested Nrf2 in models of Huntington’s disease, Parkinson’s disease, and ALS, and it is the most protective thing we’ve ever found."
“Based on the magnitude and the breadth of the effect, we really want to understand Nrf2 and its role in protein regulation better.”
First author and staff research scientist Dr Gaia Skibinski said:
“Nrf2 coordinates a whole programme of gene expression, but we didn’t know how important it was for regulating protein levels until now."
“Overexpressing Nrf2 in cellular models of Parkinson’s disease resulted in a huge effect."
“In fact, it protects cells against the disease better than anything else we’ve found.”
While Nrf2 itself may be difficult to target with a drug because it is involved in so many cellular processes, some of its downstream effects could provide the key. Scientists hope to identify other players in the protein regulation pathway that interact with Nrf2 to improve cell health and that may be easier to drug.
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A SINGLE protein could “cure” Alzheimer’s and Parkinson’s, a new study found. Controlling levels of the protein could lead to new treatments for degenerative brain diseases …