06/10/2026
PREMISE: Butt-hurt alert: given that MAHA promotes foods high in saturated fats, is this in the best interest of the general public? What does the evidence support?
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METHODS: A recent, rigorous meta-analysis of 17 randomized trials (N=66,000+ participants; x age= 46-66) evaluated saturated fat intake on lipid markers (total cholesterol, LDL-C), all-cause mortality risk, and cardiovascular events.
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RESULTS: Interventions to reduce saturated fat intake, such as replacing with mono- and/or polyunsaturated fat sources led to a significant decrease in LDL-C (RR= -3.9mg/dL), all-cause mortality (RR=0.96; 6 fewer deaths per 1000) and cardiovascular mortality (RR=0.93; 6 fewer deaths per 1000). There were additional reductions in nonfatal heart attacks (RR=0.86) and strokes (RR=0.83).
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APPLICATION: The risk reduction observed was minimal for those with a low baseline risk of cardiovascular disease. If your risk of dying from a heart attack is 1 in 10 million, a 5% increase is unlikely to significantly impact your life. Nevertheless, these findings align with the current evidence that saturated fat intake raises LDL (bad) cholesterol, which increases the risk of heart attacks and strokes. This will not make America Healthy Again. Thus, incorporate more unsaturated fats (mono and poly) and fiber, but, like anything else, be mindful and moderate the amount of saturated fat into your diet (< 10% of total kcals). Reach for relatively healthier sources like full-fat dairy, dark chocolate, or extra virgin coconut oil over butter or beef tallow.
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CITATION: doi:10.7326/ANNALS-25-02229