10/14/2026
Aggressiveness implies change over time, you need a point of comparison. Yet a biopsy captures tiny pieces of tissue at one moment in time, sampling only parts of the prostate gland.
Cancer in unsampled areas goes undetected, and more aggressive patterns are missed when they are not present in the tissue collected.
So how many biopsies should a man have in order to determine aggressiveness? Three? Twelve? Twenty? How many times should a man undergo the same invasive procedure before there is enough information to make a decision? And who decides when enough is enough?
At some point, we need to question the assumption that a biopsy is the only way to assess how aggressive a cancer is, and that men need to undergo multiple of them to protect their lives, even at the expense of their quality of life.