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11/04/2026

IABP Versus Impella for LV Unloading on VA-ECMO: HERACLES Trial

In the 24-patient randomized HERACLES trial, IABP improved a measured myocardial oxygen supply-demand ratio during VA-ECMO, while Impella CP did not. The acute physiological result does not establish better survival or recovery.

Read the full article: https://iperfusion.org/iabp-versus-impella-lv-unloading-va-ecmo-heracles/

HERACLES randomized 24 patients on VA-ECMO to IABP or Impella CP unloading. IABP improved an estimated oxygen supply-demand ratio; clinical benefit remains unproven.

11/03/2026

Beating-Heart Tricuspid Valve Surgery: Pacemaker and Survival Outcomes

A meta-analysis of six observational studies compared beating-heart and arrested-heart techniques for isolated tricuspid valve surgery. No significant differences were detected in pacemaker implantation, survival, or other major outcomes, but the evidence does not establish equivalence.

Read the full article: https://iperfusion.org/beating-heart-tricuspid-valve-surgery-outcomes/

Six observational studies compare beating-heart and arrested-heart tricuspid valve surgery, including pacemaker implantation, survival, and perfusion outcomes.

11/03/2026

Bivalirudin Versus Heparin in Cardiac Surgery: What Randomized Trials Show

Read the full article: https://iperfusion.org/bivalirudin-versus-heparin-cardiac-surgery-meta-analysis/

Three randomized trials compare bivalirudin with heparin in cardiac surgery: bleeding, transfusion, clinical outcomes, and important evidence limitations.

11/02/2026

ECMO After the Norwood Procedure: Outcomes and Limits of the Evidence

A systematic review examines mortality, intensive care recovery, and staged palliation after neonatal Norwood ECMO, with important limits on causal interpretation.

Read the full article: https://iperfusion.org/ecmo-after-norwood-procedure-outcomes/

ECMO after the Norwood procedure: a review of early mortality, ICU recovery and staged palliation, with important limits on interpreting comparative outcomes.

11/02/2026

Heart Failure and Vascular Responsiveness After Cardiopulmonary Bypass

A prospective study links chronic heart failure to reduced phenylephrine responsiveness around CPB, while exploratory vasopressin findings require clinical confirmation.

Read the full article: https://iperfusion.org/heart-failure-vascular-responsiveness-cardiopulmonary-bypass/

Heart failure and vascular responsiveness around CPB: reduced phenylephrine response and exploratory vasopressin findings from a prospective study.

11/02/2026

ECMO in Cardiogenic Shock: National Use and the Limits of Mortality Comparisons

A national Medicare study shows rising ECMO use in infarct-related cardiogenic shock and explains why claims-based mortality comparisons cannot establish treatment effects.

Read the full article: https://iperfusion.org/ecmo-cardiogenic-shock-national-use/

ECMO in cardiogenic shock: national Medicare trends, 30-day mortality, and why adjusted claims comparisons cannot establish treatment effects.

11/02/2026

Bloodless Medicine: Patient Blood Management When Transfusion Is Declined

A review of bloodless medicine connects anemia treatment, perfusion blood conservation, and individualized consent, with an update to current religious guidance.

Read the full article: https://iperfusion.org/bloodless-medicine-patient-blood-management/

Bloodless medicine review covering anemia treatment, cell salvage, perfusion blood conservation, and individualized patient consent.

11/01/2026

Topical Tranexamic Acid Mist in CABG: Bleeding and Transfusion Outcomes

A 60-patient randomized trial found less drainage and fewer red-cell transfusions with topical TXA mist after on-pump CABG, with important safety and reporting limits.

Read the full article: https://iperfusion.org/topical-tranexamic-acid-mist-cabg/

Topical tranexamic acid mist in CABG: a 60-patient randomized trial reports less drainage and red-cell exposure, with important safety and reporting limits.

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Fort Myers, FL

Telephone

+18887070010

Website

https://iperfusion.org/

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