Dr. Todd Maderis

Dr. Todd Maderis Contact information, map and directions, contact form, opening hours, services, ratings, photos, videos and announcements from Dr. Todd Maderis, Doctor, 700 Larkspur Landing Cir, Suite 205, Greenbrae, CA.

I specialize in treating Lyme disease and tickborne infections, mold-related illness, autoimmune conditions, chronic viral infections, and conditions with complex chronic illnesses - mast cell activation disorder and chronic fatigue syndrome.

09/17/2026

Patients rarely arrive at my practice with a diagnosis. They arrive with years of normal labs and no explanation.

After seeing multiple providers, three things are almost always missed: incomplete testing for tickborne infections and co-infections, inadequate assessment for mold related illness, and missed heavy metal toxicity screening. These three account for a significant share of complex chronic illness cases, and it still surprises me how often they go unchecked.

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Mold illness does not end when the exposure ends. That is one of the most important and most misunderstood facts about m...
09/16/2026

Mold illness does not end when the exposure ends. That is one of the most important and most misunderstood facts about mycotoxin illness.

When mold colonizes in the body, it continues producing mycotoxins long after a patient has left the water-damaged environment. This is why patients can be out of the moldy building for months or years and remain actively ill. The source of ongoing toxin production is internal, not environmental, and it requires a completely different treatment approach than simply removing the exposure.

Colonized mold is not treated with fluconazole or nystatin. Those medications treat yeast. Treating colonized mold requires antifungal therapies appropriate for mold species, and addressing the sinuses specifically, given their proximity to the brain and the neurological symptoms that follow sinus colonization.

Beyond colonization, mycotoxins cause damage through oxidative stress, mitochondrial dysfunction, immune dysregulation, and neurological injury simultaneously. Binders alone do not address any of those mechanisms. Recovering from mold illness requires identifying the full scope of damage and supporting cellular and mitochondrial healing as part of the treatment protocol.

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This is one of the most important clinical limitations in MCAS testing, and it directly affects how Long COVID patients ...
09/15/2026

This is one of the most important clinical limitations in MCAS testing, and it directly affects how Long COVID patients are being evaluated.

Tryptase is the most commonly ordered marker for mast cell activation. But human mast cells are capable of releasing up to 390 distinct mediators depending on the stimulus and signaling pathway involved. A normal tryptase does not confirm that mast cell activation is absent. It confirms that one mediator was not elevated at the time of collection.

Mast cell activation is also episodic. Optimal tryptase collection is within 30 minutes to two hours of symptom onset, a window most patients never have the opportunity to capture. The absence of a single elevated biomarker in a patient with a clear clinical picture of mast cell activation should not close the diagnostic conversation.

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Long COVID neuropathy is not unexplained. The mechanism is becoming increasingly clear in the research.The SARS-CoV-2 sp...
09/14/2026

Long COVID neuropathy is not unexplained. The mechanism is becoming increasingly clear in the research.

The SARS-CoV-2 spike protein activates mast cells by binding to ACE2 and TLR4 receptors, triggering the release of histamine, tryptase, and pro-inflammatory cytokines. Mast cells are positioned directly alongside peripheral nerves and blood vessels, which means when they activate, the consequences are neurological. Those mediators sensitize peripheral nerves, disrupt the blood-brain barrier, and recruit microglia, producing the neuroinflammation and small fiber nerve injury that so many Long COVID patients are experiencing.

The clinical signal supports this. When Long COVID patients with suspected mast cell activation were treated with H1 and H2 antihistamine therapy, 85% reported at least partial improvement and 29% achieved complete remission. That response pattern is not coincidental.

Comment TRYPTASE and I will send you the full 2026 study on mast cells and Long COVID neuropathy.

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09/11/2026

I have been invited to speak at the Women's .summit, a free three day virtual event happening November 10 through 12, alongside more than 40 leading physicians, researchers, and women's health experts.

My talk covers a topic I see in my practice every day, toxic metals and how they affect women's health in ways most people never suspect.

This summit goes beyond "it is just menopause." It is three days of root cause education on hormones, metabolism, inflammation, brain health, and longevity, and registration gets you access to all the live sessions. They also have replays, VIP and a Professional Pass avaiable if you want to access the content beyond the 3 days.

I would love to have you join me. Mark your calendar for November 10 through 12, and share this with any woman in your life who deserves real answers.

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Not all mold exposure starts in a water damaged building.Some of the most potent mold toxins enter through the food supp...
09/10/2026

Not all mold exposure starts in a water damaged building.

Some of the most potent mold toxins enter through the food supply. Aflatoxin B1, produced by certain molds that contaminate grains, nuts, spices, and animal feed, is considered one of the most toxic naturally occurring compounds affecting the liver. Researchers have spent decades studying its effects because of its ability to generate oxidative stress, damage mitochondria, disrupt normal liver function, and increase cellular injury.

What makes aflatoxins particularly concerning is that exposure is often invisible. Most people are not thinking about mold when they eat peanut butter, corn products, spices, or grain based foods. Yet food contamination remains one of the most common routes of exposure worldwide.

During , it is worth remembering that mold illness is not always an indoor air quality conversation. Environmental exposures can come from multiple sources, and some of the most important ones are frequently overlooked.

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09/09/2026

Aflatoxin is one of the most liver damaging mold toxins clinicians see in patients with biotoxin illness. A recent animal study looked at whether glutathione could offset that damage.

Researchers found that glutathione preserved liver structure and function despite aflatoxin exposure. It also reduced malondialdehyde, a marker of oxidative cell damage, along with inflammatory markers including interferon gamma, interleukin-6, and interleukin-8.

In my clinical practice, glutathione is a mainstay of treatment for patients with mold related illness, given either orally or intravenously.

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Most people associate mold exposure with respiratory symptoms and water damaged buildings. What receives far less attent...
09/08/2026

Most people associate mold exposure with respiratory symptoms and water damaged buildings. What receives far less attention is what mold toxins can do after they enter the body.

Aflatoxin B1 is one of the most toxic mycotoxins ever studied. It is produced by certain molds that commonly contaminate grains, nuts, spices, and animal feed. Once absorbed, the toxin is transported to the liver where it is converted into an even more reactive compound capable of damaging DNA, disrupting mitochondrial function, increasing oxidative stress, and triggering liver cell death.

The liver is responsible for processing environmental toxins, medications, hormones, and metabolic waste. When researchers study aflatoxin exposure, they consistently find evidence of inflammation, cellular injury, fibrosis, and impaired liver function. In this study, aflatoxin exposure significantly increased oxidative stress markers while reducing the body’s antioxidant defenses. Researchers also documented substantial increases in liver cell death and structural damage to liver tissue.

This is one reason mold illness can be so complex. The conversation often focuses on respiratory exposure, but food contamination remains a commonly overlooked source of mycotoxin exposure. For some individuals, understanding the full picture requires looking beyond the home environment and considering all potential sources of exposure.

Comment AFLA and I will send you the research study on aflatoxin B1 and liver damage.

Follow for clinical insights on mold illness, environmental exposures, and complex chronic illness.

The scale of mold exposure in the United States is not a fringe concern. A U.S. Environmental Protection Agency survey o...
09/03/2026

The scale of mold exposure in the United States is not a fringe concern. A U.S. Environmental Protection Agency survey of 100 representative government and commercial office buildings found that 45% had current leaks and 85% had evidence of past water damage. Schools, rental properties, and poorly maintained buildings face the same reality.

This matters clinically because mold illness is almost never the first diagnosis considered. Patients presenting with fatigue, cognitive impairment, neurological symptoms, and immune dysregulation are far more likely to receive diagnoses of fibromyalgia, chronic fatigue syndrome, or anxiety than to have their environment investigated as a potential cause. When the building a patient lives or works in is a documented source of ongoing mycotoxin exposure, no treatment protocol will produce lasting results until that exposure is identified and addressed.

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09/02/2026

Mold illness is one of the most complex and most mismanaged conditions in chronic illness, and the reasons patients stay sick are often the same across the board.

Mold does not need to be visible to cause illness. It hides inside walls, HVAC systems, and building materials, and exposure does not need to be current. Mold can colonize in the body long after the original exposure has ended, which means a patient can be out of the environment and still actively ill. That colonization, particularly in the sinuses, is rarely addressed with the therapies required to clear it. Standard antifungals like nystatin and fluconazole treat yeast, not mold, and the sinuses are almost never part of the treatment protocol despite their proximity to the brain and the neurological symptoms that follow.

The piece that is most consistently missed is the collateral damage mycotoxins leave behind at the cellular level. Without addressing mitochondrial and cell membrane dysfunction, patients remain vulnerable to downstream conditions including mast cell activation syndrome and dysautonomia, regardless of how well the infection itself is treated.

Comment MYCO and I will send you my full article on mold illness.

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Address

700 Larkspur Landing Cir, Suite 205
Greenbrae, CA

Opening Hours

Monday 9am - 5pm
Tuesday 9am - 5pm
Wednesday 9am - 5pm
Thursday 9am - 5pm

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