06/19/2026
Case of the week: Papilledema
Papilledema is defined as optic disc swelling produced from increased intracranial pressure. This excess pressure on the nerve can cause damage over time.
Causes: Benign or malignant tumors, hydrocephalus, idiopathic intracranial hypertension, stroke, venous sinus thrombosis, certain medications, etc.
Symptoms: transient vision loss, headache, double vision, nausea, and decreased visual acuity
Treatment: Treatment almost always starts with neuroimaging here. If we can rule out a tumor through a normal MRI, we can treat the intracranial hypertension with acetazolamide tablets.
Our patient underwent an MRI and received a clean report. The patient had been undergoing testosterone replacment therapy (TRT) recently. This has been linked to papilledema, although uncommon. He has stopped the TRT and has started acetazolamide to help bring the intracranial pressure back down to normal levels and control the nerve swelling.
Below are images of a swollen optic nerve and a normal optic nerve for comparison.