08/08/2026
Low-dose naltrexone, or LDN, uses a much smaller dose of naltrexone than standard therapy, typically about 1–5 mg rather than 50–100 mg.
At these lower doses, LDN is being explored for its potential effects on endorphin production, pain signaling, and immune regulation. Some patients and providers discuss LDN in connection with chronic pain, sleep, mobility, cognitive clarity, and certain autoimmune or inflammatory conditions, including Hashimoto’s thyroiditis.
LDN is generally considered well-tolerated, though side effects such as vivid dreams or headaches may occur and are often mild and temporary.
Because these lower strengths are not commercially available, LDN is typically prepared by a compounding pharmacy based on a valid prescription from a licensed provider.
Talk with your healthcare provider and our pharmacist to learn whether LDN may be appropriate for your individual needs.