Dey Lab

Dey Lab Dr. Dey is a neurosurgeon specializing in brain and spinal cord tumors. Dr Dey's lab is dedicated to discovering novel treatments for brain tumor patients.

Dr. Dey is a neurosurgeon at University of Wisconsin Madison, Department of Neurological Surgery, specializing in operations of brain and spinal cord tumors. We work on understanding the mechanisms to harvest the power of patients own immune system to attack their brain cancer cells. Dendritic cells and T cells are the two critical sub-set of immune cells that orchestrate anti-tumor immune respons

e against brain tumor cells. We work on utilizing this natural response to design novel treatment strategies for patients with malignant brain tumor (glioblastoma).

Excited to share our latest work from the lab, now published in Neuro-Oncology!In this study, we explored a novel radio...
05/14/2026

Excited to share our latest work from the lab, now published in Neuro-Oncology!

In this study, we explored a novel radiopharmaceutical therapy approach for leptomeningeal metastasis — one of the most devastating complications of solid tumors involving the central nervous system. Current treatments offer limited benefit and can cause significant toxicity.

Using tumor-targeting alkylphosphocholine NM600 labeled with Actinium-225, we demonstrated:
🧠 Improved tumor targeting within the leptomeningeal space
🎯 Greater anti-tumor efficacy compared with conventional external beam radiation
🛡️ Reduced off-target CNS toxicity
⏳ Significant survival benefit in preclinical models of breast and lung cancer leptomeningeal metastasis

These findings support the potential of targeted alpha-particle radiopharmaceutical therapy as a new therapeutic strategy for patients with CNS metastatic disease.

Proud of this incredible multidisciplinary team and grateful to all our collaborators who made this work possible. Special congratulations to the trainees and co-authors whose dedication drove this project forward.

This is an exciting breakthrough for brain cancer research! 🧠✨We’ve just published new findings in  on using human neura...
05/12/2026

This is an exciting breakthrough for brain cancer research! 🧠✨

We’ve just published new findings in on using human neural organoids—often called “mini-brains”—to model Diffuse Midline Glioma (DMG). This aggressive pediatric brain tumor has historically been incredibly difficult to study and treat because of its complexity and location.

Here’s why this matters:
• Real-World Complexity: Unlike traditional cell cultures, these 3D organoids replicate the intricate environment of a human brain, allowing us to see how DMG cells invade and interact with healthy neural tissue.

• Patient-Specific Insights: By using patient-derived cells, we can capture the unique genetic and structural “fingerprint” of an individual’s tumor.

• Better Drug Testing: This model provides a more accurate “test track” for new therapies, hopefully bridging the gap between the lab and the clinic.

We are one step closer to understanding the “how” and “why” behind these tumors, paving the way for more effective, personalized treatments.

Congratulations to all the co-authors for their contributions and .shireman for bringing this all together!!

Words can’t begin to describe how proud I am of Jack Shireman and all that he has accomplished  and more importantly, al...
05/07/2026

Words can’t begin to describe how proud I am of Jack Shireman and all that he has accomplished and more importantly, all that he is going to contribute to the world of Neuro-oncology.
Jack is my first graduate student. When he first reached out to pursue a PhD in my lab, I honestly wasn’t even sure I was ready for the commitment of training a graduate student. But his passion, curiosity, and enthusiasm for Neuro-oncology were impossible to ignore, and from that moment on, I never looked back.
Over the years, we went through many highs and lows together, both professionally and personally and I can say without hesitation that I am a better person because of that journey. Mentoring Jack taught me so much about myself: patience, when to push, when to listen, and when simply being a friend matters most.
Watching him graduate feels a little like watching your first child step into the world. My heart is incredibly full.
Jack has grown into an exceptional scientist with a remarkable foundation in Neuro-oncology, Neurosurgery, Immunology, and Computational science. But beyond his accomplishments, he is someone whose compassion, resilience, and drive will leave a lasting impact on patients, science, and everyone lucky enough to work with him.
Congratulations, Dr. Jack Shireman. The future of Neuro-oncology is brighter because of you.

Jack Shireman has long been driven to better understand brain tumors and how they can be treated more effectively. That interest shaped his undergraduate studies in neurobiology at UW–Madison, his years in research labs at Northwestern and ultimately his decision to return to UW to pursue a doctorate in neuroscience.
When Jack talks about the UW School of Medicine and Public Health, he points to how closely science, medicine and community are linked. “When I think about the mission of UW, I think about how UW has taught me not only about the basic science behind health but also how the health of a whole person and community is intertwined,” he said.
That connection became personal long before graduate school. As a teenager, Jack received treatment for a brain tumor from pediatric oncology faculty who cared for him at American Family Children’s Hospital. Experiencing care at UW where he now trains helped shape his commitment to brain tumor research and his goal of becoming a physician‑scientist.
In his research at UW, Jack studied brain tumor immunotherapy, using translational models and patient data to analyze treatment resistance and improve future therapies. He points to the UW environment, where clinicians and researchers collaborate closely from the lab to the patient bedside. That experience was reinforced by his own mentor, Dr. Mahua Dey, who treats patients with brain tumors while leading a lab focused on those same diseases. Beyond the lab, Jack is active in sharing science with broader audiences—from presenting research at the Wisconsin State Capitol to tutoring UW students and participating in community outreach that makes complex research more accessible.
This fall, Jack will start medical school at the Medical College of Wisconsin, continuing his training as a physician-scientist. For him, advancing brain tumor research is not just about discovery, but about contributing to healthier people and healthier communities.
We congratulate all graduate students who successfully completed their studies across the school’s 13 graduate programs and seven affiliated graduate programs.

🧠 Bridging Intelligence: Human & Artificial 🤖What happens when you bring together the world’s leading neuro-oncologists ...
05/01/2026

🧠 Bridging Intelligence: Human & Artificial 🤖

What happens when you bring together the world’s leading neuro-oncologists and the brightest minds in AI? You get a glimpse into the future of brain tumor treatment.

Our **AI in Neuro-Oncology Virtual Meeting** just wrapped up, and the energy (even through the screen!) was incredible. From automating tumor segmentation to predicting treatment responses through radiomics, the potential to improve patient outcomes is no longer “science fiction”—it’s happening in our labs right now.

🚀 Key Takeaways:

* **Precision Diagnostics:** How deep learning is identifying molecular markers faster than traditional pathology.

* **Scalable Solutions:** The move toward making advanced AI tools accessible to clinics worldwide, not just academic hubs.

* **The Human Element:** AI isn’t replacing the physician; it’s providing the “superpowers” needed to make data-driven decisions at lightning speed.

💡 Notable Quote:
“correlation is not causation”

A massive thank you to our speakers, moderators, and all the attendees who joined us from across the globe. Special Thanks to Janelle for pulling this all together!! And it is always a vibe to host these meetings with amazing Dr Bovi!!

The fight against brain cancer is uphill, but with these tools in our kit, the peak is finally in sight.
Missed a session? Stay tuned for the recorded highlights coming soon! 📺

The “Dream Team” in action! 💫A massive thank you to the incredible scientists, students, and their families of the Dey L...
04/13/2026

The “Dream Team” in action! 💫

A massive thank you to the incredible scientists, students, and their families of the Dey Lab for generously volunteering their time in making this year’s “Hands-on Brain Surgery” demonstration a total success, again! 🧠✨

We spent the day at the Carbone Cancer Center Open House, where we got to engage with our community and hopefully inspire the next generation of neurosurgeons. This work—and the mission to bridge the gap between the lab and the public—wouldn’t be possible without this amazing group.
So proud of what we’ve built together! 🧫🔬

Thanks Xiahou, .shireman , Lei, Yilong, Samantha, Cheyanne for making this THE best event

Transforming Brain Tumor Care with AI 🧠🤖The future of neuro-oncology is here. Join us for the Sixth Annual Wisconsin Pri...
04/09/2026

Transforming Brain Tumor Care with AI 🧠🤖

The future of neuro-oncology is here. Join us for the Sixth Annual Wisconsin Primary CNS Malignancy Symposium, where we will explore the integration of Artificial Intelligence into clinical practice and research. Hear from the leading experts in the field.

From ethical considerations to AI-enabled diagnostic tools, this symposium is designed for clinicians and researchers looking to bridge the gap between emerging technology and patient outcomes.

• 📅 Date: April 24, 2026
• ⏰ Time: 7:45 AM – 1:00 PM CST
• 📍 Format: Virtual
• 🔗 Register here: go.wisc.edu/8ha0u0

Presented by UW School of Medicine and Public Health, Medical College of Wisconsin, and ThedaCare.

🧠 Ever wanted to try your hand at brain surgery? Now’s your chance! 🧠Join us at the UW Health Carbone Cancer Center Open...
04/01/2026

🧠 Ever wanted to try your hand at brain surgery? Now’s your chance! 🧠

Join us at the UW Health Carbone Cancer Center Open House and learn the techniques of a neurosurgeon using our special “Jello Brain Surgery” display.

This is a unique, hands-on opportunity to:
• Use actual surgical tools to “operate” on a realistic brain model.
• Learn about the precision and skill required in cancer treatment.
• Interact directly with our world-class researchers and neuroscientists.

It’s just one of the 20+ interactive exhibits designed to bring cancer research to life for all ages.

📅 When: Sunday, April 12, 2026, from 12–4 p.m.
📍 Where: Health Sciences Learning Center, 750 Highland Avenue, Madison
🎟️ Cost: FREE!

Don’t miss out on this incredible learning experience and other exhibits, including giant inflatable organs, behind-the-scenes lab tours, and Babcock ice cream. The first 500 people receive a FREE gift!

Mark your calendars for an afternoon of discovery. Tag a friend who needs to try this!

👉 Learn more: uwhealth.org/carbone-openhouse

🧠 New Insights into Cavernous Sinus MeningiomasDon’t miss the next installment of Latest Highlights in Neurosurgical Onc...
03/31/2026

🧠 New Insights into Cavernous Sinus Meningiomas

Don’t miss the next installment of Latest Highlights in Neurosurgical Oncology, featuring a deep dive into one of the most complex areas of skull base surgery.

Join world renowned Dr. Jacques Morcos for an expert session on the management and surgical nuances of Cavernous Sinus Meningiomas.

🗓️ Event Details
• Date: Wednesday, April 8th
• Time: 3:30 PM CST
• Host: Dr. Yoshua Esquenazi (UT Health Houston)

🎙️ Featured Panelists
• Dr. Costas Hadjipanayas
• Dr. Mahua Dey
• Dr. Spyros Karadimas
• Dr. Hussam Abou-Al-Shaar

🔗 How to Join
Join the conversation and stay at the forefront of neuro-oncology. Register or join the session directly via the link below or by scanning the QR code in the image:
👉 rebrand.ly/q5mbl6t

Welcome to the Greatest Field in Medicine 🧠⚡️Huge congratulations to the newest cohort of Neurosurgery residents! 🥂 You’...
03/21/2026

Welcome to the Greatest Field in Medicine 🧠⚡️
Huge congratulations to the newest cohort of Neurosurgery residents! 🥂 You’ve officially matched into the most demanding, exhilarating, and rewarding specialty in existence.
The road ahead is long, and the training is legendary for its intensity—but the privilege of holding a human life (and their entire world) in your hands is a reward that words can’t quite capture.
To the Match Class of 2026:
• Prepare for the steepest learning curve of your life. 📈
• Embrace the late nights and the complex cases.
• Welcome to the family. We can't wait to see what you achieve.
Drop a 🧠 or a 🔪 in the comments if you’re joining the ranks today!

🌸 Fertility. Cancer. The Questions We Don’t Ask Enough. 🌸In our previous research on glioma and pregnancy, our team saw ...
03/04/2026

🌸 Fertility. Cancer. The Questions We Don’t Ask Enough. 🌸

In our previous research on glioma and pregnancy, our team saw firsthand how deeply cancer diagnosis and treatment can impact fertility, reproductive health, and life planning.
Now, the Dey Lab is taking the next step.
We are surveying biological female cancer patients diagnosed between ages 18–49 to better understand current practice patterns surrounding fertility counseling, preservation options, and reproductive health after a cancer diagnosis.

Your voice matters.
Your experience matters.
And your story can help improve care for future patients.
If you are eligible — or know someone who may be — please consider participating and sharing this flyer.

Use the link in the comment or scan the QR code above to access the survey.
Together, we can build a future where cancer care fully supports survivorship, fertility, and reproductive choice. 💜

Address

600 Highland Avenue K4/879 CSC
Madison, WI
53792

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