Dr. Jamie Koufman, Respiratory Reflux Expert

10/21/2026

Suffer from a chronic cough, throat clearing, or hoarseness without heartburn? You might have silent reflux (LPR)—and common acid reflux meds might not be helping. Dr. Koufman breaks down why PPIs fail, the power of a low-acid diet, and the most effective treatments to heal your airways.

Read the full blog here: https://jamiekoufman.com/a-doctors-guide-to-treatment-of-silent-reflux-respiratory-reflux-and-lpr-2/

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Schedule a consultation: www.jamiekoufman.com/consulting

Understanding Different Types of Reflux Effective treatment begins with understanding that not all reflux is the same. While GERD (gastroesophageal reflux disease) is the most widely recognized, it is neither the most prevalent nor the most harmful type of reflux. Silent reflux, which is harder to d...

10/07/2026

Could the future of reflux treatment go beyond acid suppression?

For millions living with LPR and Respiratory Reflux, PPIs don’t always provide lasting relief. One reason may be pepsin, an enzyme that can remain in throat and respiratory tissues even when acid is reduced.

In this episode of Reflux Hour, Dr. Jamie Koufman explores the science behind pepsin-targeted therapies, including Amprenavir/Fosamprenavir, and what they could mean for the future of non-acid and silent reflux treatment.

🔬 Fascinating science.
💡 Exciting possibilities.
🎙️ A FANTASTIC episode for anyone interested in the future of reflux care!

Standard reflux treatments have relied on Proton Pump Inhibitors (P...

10/07/2026

The cure for acid reflux, respiratory reflux, LPR, heartburn, and GERD: Fosamprenavir protects against pepsin binding and cell damage

10/06/2026

Tune in tomorrow!!

Standard reflux treatments have relied on Proton Pump Inhibitors (PPIs) to reduce stomach acidity. However, for millions living with LPR (Laryngopharyngeal Reflux) and Respiratory Reflux, acid suppression alone fails to provide lasting relief. The reason? Pepsin.

Even at non-acidic pH levels, pepsin remains bound to cellular membranes in the throat and lungs, reactivating whenever acidic foods or beverages are consumed.
In this episode of Reflux Hour, Dr. Jamie Koufman dives deep into the protective mechanism of Amprenavir:
1. How Pepsin Causes Cell Damage: Pepsin enters non-acidic respiratory tissues via reflux events, endocytosing into epithelial cells where it disrupts structural integrity.
2. The Amprenavir Mechanism: Research indicates that Amprenavir binds to pepsin, effectively inhibiting its ability to attach to host tissues and cause cellular injury.
3. Clinical Implications: Understanding how targeted enzyme inhibitors could revolutionize the therapeutic landscape for non-acid and silent reflux.

Whether you are a patient struggling with throat symptoms or a healthcare provider looking for advanced reflux management strategies, this discussion offers key scientific context on the future of pepsin-targeted therapies.

Tune in next Wednesday at 12pm EST to hear more!

09/30/2026

Standard reflux treatments have relied on Proton Pump Inhibitors (PPIs) to reduce stomach acidity. However, for millions living with LPR (Laryngopharyngeal Reflux) and Respiratory Reflux, acid suppression alone fails to provide lasting relief. The reason? Pepsin.

Even at non-acidic pH levels, pepsin remains bound to cellular membranes in the throat and lungs, reactivating whenever acidic foods or beverages are consumed.
In this episode of Reflux Hour, Dr. Jamie Koufman dives deep into the protective mechanism of Amprenavir:
1. How Pepsin Causes Cell Damage: Pepsin enters non-acidic respiratory tissues via reflux events, endocytosing into epithelial cells where it disrupts structural integrity.
2. The Amprenavir Mechanism: Research indicates that Amprenavir binds to pepsin, effectively inhibiting its ability to attach to host tissues and cause cellular injury.
3. Clinical Implications: Understanding how targeted enzyme inhibitors could revolutionize the therapeutic landscape for non-acid and silent reflux.

Whether you are a patient struggling with throat symptoms or a healthcare provider looking for advanced reflux management strategies, this discussion offers key scientific context on the future of pepsin-targeted therapies.

Tune in next Wednesday at 12pm EST to hear more!

09/21/2026

Could your “sinus problems,” chronic cough, asthma, or even sleep issues actually be connected to reflux? 👀

Dr. Jamie Koufman explains why respiratory reflux can look very different from traditional heartburn—and why it’s so often overlooked or misdiagnosed.

From pepsin and tissue damage to late-night eating, soda, alcohol, reflux testing, and why the right lifestyle changes may matter more than you think, her latest blog post breaks it all down.

👉 Click the link to read Dr. Koufman’s full post and learn more about respiratory reflux. https://jamiekoufman.com/10-things-you-should-know-about-acid-reflux-2/

You may be surprised by what’s really behind your symptoms.

Discover 10 overlooked facts about acid reflux and respiratory reflux—often the real cause of chronic cough, hoarseness, or shortness of breath

09/15/2026

🔎 Have a question about reflux, LPR, or your respiratory health? Start with the blog!

Did you know you can search Dr. Jamie Koufman’s blog for answers to your questions? With a wide array of topics covering reflux, LPR, GERD, respiratory symptoms, diet, treatment, and more, there’s a wealth of information waiting to be explored.

Whether you’re looking for answers to a specific concern or simply want to learn more about how reflux can affect your health, the blog is a great place to start.

💡 Have a question? Search the blog and discover the answers!
Explore the blog at

Dr. Koufman’s Treatment for Three Vagally-Mediated Neurogenic Symptoms: Painful Speaking, Chronic Sore Throat, and Cough

09/03/2026

Did you know that for over 50 years, millions of people with LPR, respiratory reflux, and GERD have been grossly misdiagnosed and mismanaged?

In this month’s Reflux Hour, internationally renowned reflux pioneer Dr. Jamie Koufman breaks down five decades of medical missteps, why traditional treatments often fail, and what you actually need to do to heal.

Follow me on FB: Facebook.com/DrJamieKoufman
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Schedule a consultation: www.jamiekoufman.com/consulting

https://www.youtube.com/watch?v=5bjUP4ZpMHA

Did you know that for over 50 years, millions of people with LPR, r...

09/02/2026

Respiratory Reflex, LPR, and GERD:
50 Years of Gross Mismanagement

08/27/2026

Join Dr. Koufman for Dr. Koufman’s Reflux Hour this Wednesday, September 2 at 12:00 PM EST for a critical discussion on a major healthcare breakdown!

For half a century, traditional medicine has misdiagnosed, mismanaged, and mistreated millions of people suffering from Laryngopharyngeal Reflux (LPR) and Respiratory Reflux. By treating LPR with the same playbook as standard GERD—relying heavily on long-term proton pump inhibitors (PPIs) while ignoring airway symptoms—the medical establishment has left patients struggling with chronic throat clearing, cough, hoarseness, post-nasal drip, and asthma-like symptoms without true relief.

Don't miss this eye-opening session to learn how to take control of your health and escape the cycle of ineffective treatments!