American Society of Pediatric Nephrology

08/29/2026

A self-sustaining hypoxia inducible factor-1α–creatine kinase B feedforward circuit drives macrophage-mediated kidney fibrosis

https://buff.ly/1qWDQTm

A fundamental challenge in treating chronic kidney disease (CKD) is the lack of therapies to reverse established fibrosis. While systemic hypoxia sensors like erythrocyte sphingosine kinase 1 (eSPHK1) can initiate fibrotic signaling, the mechanisms driving self-perpetuating and progressive fibrosis....

08/29/2026

Genetic determinants of serum creatinine and cystatin C independent of kidney function generate bias in filtration markers

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Non-GFR determinants of filtration markers reduce the accuracy of estimated GFR (eGFR) and genetic factors may explain part of this reduced performance. Here, we identify genetic variants associated with serum levels of creatinine or cystatin C (but not GFR), compute their effect, and investigate ca...

08/29/2026

Generation of a novel Slc7a9G105R mutant mouse identifies new biomarkers for cystinuria


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Cystinuria is a rare inherited disease characterized by increased urinary cystine levels resulting in the formation of cystine stones in the urinary tract. Mutations in the genes encoding the cystine transporter complex, SLC3A1 and SLC7A9, are the primary drivers of the disease. Current mouse models...

08/28/2026

Resilience assessed by Resilience Scale (RS-14) in young people living with chronic kidney disease and its relationship with depressive and anxiety symptoms


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Home Pediatric Nephrology Article Resilience assessed by Resilience Scale (RS-14) in young people living with chronic kidney disease and its relationship with depressive and anxiety symptoms Research Letter Open access Published: 11 August 2026 (2026) Cite this article You have full access to this o...

08/28/2026

Health-related quality of life in children with kidney failure and caregiver–child discordance: a prospective cohort study using PedsQL 3.0 ESRD Module


https://buff.ly/41l5Ae0

Home Pediatric Nephrology Article Health-related quality of life in children with kidney failure and caregiver–child discordance: a prospective cohort study using PedsQL 3.0 ESRD Module Research Letter Open access Published: 11 August 2026 (2026) Cite this article You have full access to this open...

08/28/2026

Review: Tailoring HLA antibody monitoring post-transplantation


https://buff.ly/Qfv7225

Abstract Human leukocyte antigen (HLA) donor-specific antibodies (DSA) are among the most important determinants of late allograft loss after kidney transplantation. However, no uniform monitoring strategy has been validated in pediatric recipients. This educational review recommends that post-trans...

08/27/2026

Blood pressure patterns in adolescents with premenstrual syndrome: office, home, and ambulatory blood pressure monitoring across the menstrual cycle

https://link.springer.com/article/10.1007/s00467-026-07517-x?error=cookies_not_supported&code=315b2be8-786a-4df3-97c2-65ad422e9d59

08/27/2026

Clinical and genetic spectrum of distal renal tubular acidosis in children: findings from Indian tubular disorders registry

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Introduction Distal renal tubular acidosis (dRTA) is a heterogeneous group of disorders of impaired distal acid secretion, leading to normal anion gap metabolic acidosis, growth failure and nephrocalcinosis. Although a genetic basis is well established, the genetic aetiology may differ in Asian popu...

08/27/2026

Evolocumab for severe refractory hypercholesterolemia in a child with steroid-resistant nephrotic syndrome and membranous nephropathy

https://link.springer.com/article/10.1007/s00467-026-07521-1?error=cookies_not_supported&code=e4e81d90-7910-40f2-a3e2-eab807b8fd1e

08/27/2026

Review: Monoclonal and monotypic immunoglobulin-related kidney diseases in young people: literature review including evolving entities

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Monoclonal gammopathy, paraprotein secreted by a clonal B-lymphoproliferative or plasma cell disorder, is quite rare in children and adolescents and may be transient. Kidney injury related to monoclonal proteins, or monoclonal gammopathy of renal significance (MGRS), is correspondingly rare and may....