Direct Primary Care Mebane

06/01/2026

Our office will be closed this Thursday 6/4.

05/23/2026

Social media influencers make everyone with an MTHFR SNP think they need to be on high doses of methylated folate and B12. This is not good advice. There are other genes to consider in the methylation pathways such as COMT. Over methylation can not only cause mood imbalances such as anxiety but cancer also benefits from both over methylation and under methylation.

Risk of over methylation and under methylation in cancer:

The relationship between methylation and cancer is complex because both overmethylation and undermethylation (hypomethylation) can contribute to cancer development or progression — but in different ways.

What “methylation” means in cancer
Methylation usually refers to adding a methyl group (CH₃) to DNA, proteins, neurotransmitters, hormones, or detoxification pathways. In cancer biology, the most important issue is often DNA methylation, which affects whether genes are turned on or off.

A simplified way to think about it:

Too much methylation in the wrong places → can silence protective genes

Too little methylation overall → can destabilize DNA and activate harmful genes

Both patterns are commonly seen in tumors simultaneously.

Why this matters.

Hypermethylation can silence:

Tumor suppressor genes
DNA repair genes
Cell cycle regulation genes
Immune surveillance genes

Examples include silencing of:

BRCA-related pathways
MLH1
p16
APC

This can help tumors evade normal growth control.

If you have cancer or are at increased risk of cancer please work with a functional medicine provider who understands cancer instead of listening to social media influencers.

05/09/2026

We are watching the Hantavirus information. Most Hantavirus strains are spread by rodents. The Andes strain can spread human to human in very close contact. Prior to the cruise ship spread there are only a few known cases of human to human transmission. I have been doing research on the pathophysiology of the virus and am aware of therapies that may be helpful if this becomes an issue.

04/30/2026

Our office has moved. We are now at 1107 South 5th Street Mebane, NC suite 101

04/19/2026

Conventional medical models often interpret laboratory results using a binary “normal vs. abnormal” framework. In contrast, our approach emphasizes identifying optimal ranges that support overall health and long-term well-being—not simply the absence of disease.

Relying solely on standard reference ranges can overlook early imbalances and subclinical dysfunction, which may leave patients feeling unheard or dismissed despite ongoing symptoms. A more comprehensive interpretation allows for earlier intervention and a more personalized, patient-centered approach to care.

Send a message to learn more

04/19/2026

Being a patient at Direct Primary Care Mebane means having a provider who doesn’t rely on outdated protocols or rushed, one-size-fits-all care. It means working with someone who stays current with evolving research, questions conventional norms when appropriate, and is willing to dig deeper to find the most effective, up-to-date approaches for your health.

It’s an integrative model that looks at the whole picture- lifestyle, nutrition and prevention—not just symptoms.

You’re not just another chart. Your provider takes the time to research, collaborate, and personalize your care plan so you’re getting thoughtful, evidence-informed guidance—not guesswork.
This is what modern, patient-centered care should look like.

04/19/2026

Being a patient at Direct Primary Care Mebane means having a provider who doesn’t rely on outdated protocols or rushed, one-size-fits-all care. It means working with someone who stays current with evolving research, questions conventional norms when appropriate, and is willing to dig deeper to find the most effective, up-to-date approaches for your health.

It’s an integrative model that looks at the whole picture- lifestyle, nutrition and prevention—not just symptoms.

You’re not just another chart. Your provider takes the time to research, collaborate, and personalize your care plan so you’re getting thoughtful, evidence-informed guidance—not guesswork.

This is what modern, patient-centered care should look like.

04/09/2026

Our office is closed today and will reopen tomorrow.

04/08/2026

We have an open position for a massage therapist trained in deep tissue, psoas and plantar fasciitis massage. This is a W2 position with CE benefits. Please send resumes to [email protected]

Send a message to learn more

04/03/2026

I am happy to see that there are oncologists looking into hormones after breast cancer. There are several published studies showing estradiol decreases risk of breast cancer. Now we need studies for our cancer survivors. We should not leave these women at increased risk of osteoporosis, cardiovascular disease, dementia and poor quality of life if it is safe to give hormones after breast cancer treatment.

https://ascopubs.org/doi/10.1200/JCO-25-03121