03/19/2026
Day 4: Tianeptine
Tianeptine is a substance that has recently gained attention across the United States due to its increasing availability and potential for misuse. While it was originally developed as an antidepressant in some countries, tianeptine is not approved for medical use in the U.S. Despite this, it is often sold in gas stations, convenience stores, and online as a dietary supplement or “nootropic.”
At high doses, tianeptine can act on opioid receptors, producing effects similar to opioids and increasing the risk of dependence, addiction, and withdrawal symptoms when use stops. Some products marketed under names like ZaZa, Tianna, or Neptune’s Fix have been linked to serious health concerns and poison control calls.
Understanding substances like tianeptine is important for communities, clinicians, and families. Education and awareness can help people recognize risks and make informed decisions about their health and safety.