08/14/2026
So what exactly do GLP-1 medications do — especially in teens?
GLP-1 medications work on the biology of appetite. They act on pathways in the brain involved in hunger and fullness and can slow gastric emptying, helping teens feel fuller and reducing hunger and energy intake.¹
And we have pediatric data.
In the STEP TEENS trial, adolescents with obesity treated with semaglutide plus lifestyle intervention had significantly greater reductions in BMI than those receiving lifestyle intervention alone.² Liraglutide has also demonstrated efficacy in adolescents with obesity.³
But here’s the part I think we need to talk about more:
A GLP-1 is a tool. It is not the whole treatment plan.
It doesn’t teach your teen how to nourish their body.
It doesn’t build an exercise routine they can sustain.
It doesn’t fix inadequate sleep.
And it doesn’t address stress, body image, emotional eating, or their relationship with food.
That’s why pediatric obesity care should be comprehensive — medication when appropriate, alongside nutrition, movement, behavioral support, and ongoing medical care. The AAP specifically recommends pharmacotherapy as an adjunct to health behavior and lifestyle treatment, not a replacement for it.⁴ (American Academy of Pediatrics)
The medication can help change the biology.
We still have to care for the whole teen.
Follow for evidence-based conversations about GLP-1s and weight management specifically for teens.
Sources:
¹ AAP Clinical Practice Guideline, Pediatrics, 2023.
² Weghuber et al., NEJM, 2022 (STEP TEENS).
³ Kelly et al., NEJM, 2020.
⁴ AAP Clinical Practice Guideline, pediatrics, 2023.