The Mindich Child Health and Development Institute

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The Mindich Child Health and Development Institute

The Mindich Child Health & Development Institute is a research enterprise whose mission is to advance knowledge & therapies for diseases affecting children

The Mindich Child Health and Development Institute is a translational research enterprise with the mission of advancing knowledge and therapies for diseases affecting infants, children, and adolescents. Led by Bruce D. Gelb, MD, the MCHDI provides an intellectually rich and supportive environment for fostering collaborative scientific investigation and Mount Sinai’s “bench to bedside” philosophy,

as well as training the next generation of scientific leaders in pediatric medicine. Physician-scientists and scientists at the MCHDI work in a multidisciplinary manner with researchers and physicians in various departments and institutes at Mount Sinai. Together, we strive toward the objectives of developing robust paradigms for understanding the effects of genetics and environment on the health of infants, children and adolescents, and personalizing pediatric medicine through genetics and genomics. Our main areas of research focus include:

-Allergy & Asthma
-Cardiovascular Disease
-Neurodevelopmental Disorders
-Obesity & Diabetes

For a full list of our faculty members please visit:

http://icahn.mssm.edu/research/institutes/child-health-and-development-institute/team

07/10/2026

EHR-based marker flags patients at risk of rejection

Eyal Shemesh, MD, discusses his research suggesting that a novel electronic health record-based marker can help clinicians identify transplant patients at high risk for organ rejection due to not taking their medications as prescribed, allowing them to intervene before rejection occurs.

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An EHR-based marker can flag transplant patients at high risk of organ rejection and cut rejection rates to low-risk levels, a new study found.

07/01/2026

Patient-derived mini reveal mechanism and treatment for rare disease

Eva Morava, MD, PhD, and Tamas Kozicz, MD, PhD, discuss their research on the first cortical brain organoid models of dehydrodolichyl diphosphate synthase (DHDSS)-related disease, a condition with no current treatments.

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Dehydrodolichyl diphosphate synthase (DHDSS)-related disease has no available treatments. The new work could finally change that with nicotinamide mononucleotide (NMN).

06/26/2026

Study connects common to preterm , other health risks

Shelley Liu, PhD, discusses research finding that women are exposed to dozens of chemicals every day, many of which are linked to birth and low birth .

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A large study of chemical exposures during pregnancy has found that pregnant women are exposed to dozens of chemicals everyday, many of which are linked to preterm births and low birth weights. The chemicals showed up in a vast array of products, highlighting the massive scope of exposure for expect...

06/12/2026

Childhood fall as early introduction becomes more common, new study finds

Scott Sicherer, MD, discusses research finding that after a major shift in guidance from delaying allergenic foods until 1 to 3 years of age to introducing them by 6 months of age, the prevalence of egg allergy among declined.

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Parents used to be advised to keep allergenic foods like eggs away from babies, especially if allergies ran in the family. But based on recent and evolving evidence, the advice is now almost the opposite – and new research suggests the shift in guidance is paying off.

06/05/2026

Researchers uncover a substantial component to

Behrang Mahjani, PhD, Veerle Bergink, MD, PhD, and Seulgi Jung, PhD, a postdoctoral fellow in the Mahjani Lab at Mount Sinai, discuss their research uncovering a substantial genetic component to postpartum psychosis, a rare but severe illness that occurs in the days to weeks after .

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Researchers at the Icahn School of Medicine at Mount Sinai have uncovered a substantial genetic component to postpartum psychosis, a rare but severe psychiatric illness that occurs in the days to weeks after childbirth. The findings, published in Molecular Psychiatry, provide new evidence that the c...

05/29/2026

Effects of early to

Megan Horton, PhD, discusses her research combining naturally shed baby with advanced imaging to pinpoint specific weeks during and infancy when the developing brain appears most vulnerable to .

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Scientists found that toxic metal exposures during specific time windows increased the risk of brain and mental health symptoms a decade later.

05/22/2026

Psychotropic Prescribing in : Balancing Teratogenic Risk and Relapse Prevention

Veerle Bergink, MD, PhD, discusses the pharmacological management of severe illness during pregnancy and the period, with emphasis on relapse prevention, as presented at the American Psychiatric Association 2026 meeting.

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Planning for prevention of perinatal psychiatric relapse with safer medication options.

05/07/2026

Liver and Muscle Cells Influence Following

Brian Brown, PhD, Joshua Brody, MD, and Sophia Siu, an MD/PhD student at the Icahn School of Medicine at Mount Sinai, discuss their research overturning a longstanding assumption about how mRNA vaccines generate immunity, revealing that certain non-immune cells help determine vaccine effectiveness.

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A study showed that non-immune cells shape mRNA vaccine responses. Expression of mRNA in muscle cells increased immunity, while expression in the liver reduced it. The findings could have broad implications in vaccines, oncology, and autoimmunity.

05/01/2026

Surprising links between , 's could change how we treat both

Joseph Buxbaum, PhD, discusses his research on the potential connection between autism and Alzheimer’s.

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The idea that two conditions at opposite ends of life might be biologically linked is beginning to upend long-standing assumptions in brain science, blurring a divide that has shaped the field.

04/24/2026

New Study Reveals Why Commonly Starts in

Shruti Naik, PhD, and Emma Guttman, MD, PhD, detail their recent study which sheds new light on the biological mechanisms that underlie the early onset of eczema in childhood.

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In a groundbreaking study published in Nature on February 25, 2026, scientists from the Icahn School of Medicine at Mount Sinai, Weill Cornell Medicine, and collaborating institutions have shed new

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