The Mindich Child Health and Development Institute

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The Mindich Child Health and Development Institute

The Mindich Child Health & Development Institute is a research enterprise whose mission is to advance knowledge & therapies for diseases affecting children

The Mindich Child Health and Development Institute is a translational research enterprise with the mission of advancing knowledge and therapies for diseases affecting infants, children, and adolescents. Led by Bruce D. Gelb, MD, the MCHDI provides an intellectually rich and supportive environment for fostering collaborative scientific investigation and Mount Sinai’s “bench to bedside” philosophy, as well as training the next generation of scientific leaders in pediatric medicine. Physician-scientists and scientists at the MCHDI work in a multidisciplinary manner with researchers and physicians in various departments and institutes at Mount Sinai. Together, we strive toward the objectives of developing robust paradigms for understanding the effects of genetics and environment on the health of infants, children and adolescents, and personalizing pediatric medicine through genetics and genomics. Our main areas of research focus include:

-Allergy & Asthma
-Cardiovascular Disease
-Neurodevelopmental Disorders
-Obesity & Diabetes

For a full list of our faculty members please visit:

http://icahn.mssm.edu/research/institutes/child-health-and-development-institute/team

08/21/2026

Youth-associated protein reverses age-related changes in

Joseph Castellano, PhD, discusses his research identifying a role for the youth-associated protein TIMP2 in supporting the healthy function of microglia, the brain’s resident immune cells.

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Researchers at The Icahn School of Medicine at Mount Sinai have identified a role for the youth-associated protein TIMP2 in supporting the healthy function of microglia, the brain's resident immune cells.

08/14/2026

7 Top Questions About &

Andrea Dunaif, MD, discusses the top questions women have about PMOS and pregnancy.

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Polyendocrine metabolic ovarian syndrome, formerly called PCOS, interferes with your ability to ovulate, which can make it harder to get pregnant.

08/07/2026

Indoor & ’s Health: Tips for Healthier Breathing at Home

Lauren Zajac, MD, MPH, discusses what you need to know about indoor air quality and your child's health, with practical ways to help everyone in your family breathe easier.

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Find out why indoor air pollution poses serious health risks for your child, now and throughout life. Get tips for cleaner air at home, school & more.

07/24/2026

Forever ’ linked to gut in after early

Vishal Midya, PhD, MStat, study co-author and researcher, explains he and his colleagues' work which found that and early life exposure to mixtures is probably linked to higher levels of intestinal inflammation in children, new first-of-its-kind research shows.

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Researchers tracked mother-child pairs for up to 11 years, finding Pfas mixtures may affect developing guts

07/17/2026

Testing Reveals That -Linked Syndrome Is More Common Than Previously Thought

Joseph Buxbaum, PhD, and Tess Levy, MSc, discuss their research estimating that Phelan-McDermid syndrome affects approximately 1 in 7,300 people, making it dramatically more common than previous estimates suggested.

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A large genetic study found Phelan-McDermid syndrome is much more common than earlier estimates suggested. Expanding genetic testing could identify thousands of undiagnosed people and improve access to specialized care.

07/10/2026

EHR-based marker flags patients at risk of rejection

Eyal Shemesh, MD, discusses his research suggesting that a novel electronic health record-based marker can help clinicians identify transplant patients at high risk for organ rejection due to not taking their medications as prescribed, allowing them to intervene before rejection occurs.

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An EHR-based marker can flag transplant patients at high risk of organ rejection and cut rejection rates to low-risk levels, a new study found.

07/01/2026

Patient-derived mini reveal mechanism and treatment for rare disease

Eva Morava, MD, PhD, and Tamas Kozicz, MD, PhD, discuss their research on the first cortical brain organoid models of dehydrodolichyl diphosphate synthase (DHDSS)-related disease, a condition with no current treatments.

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Dehydrodolichyl diphosphate synthase (DHDSS)-related disease has no available treatments. The new work could finally change that with nicotinamide mononucleotide (NMN).

06/26/2026

Study connects common to preterm , other health risks

Shelley Liu, PhD, discusses research finding that women are exposed to dozens of chemicals every day, many of which are linked to birth and low birth .

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A large study of chemical exposures during pregnancy has found that pregnant women are exposed to dozens of chemicals everyday, many of which are linked to preterm births and low birth weights. The chemicals showed up in a vast array of products, highlighting the massive scope of exposure for expect...

06/12/2026

Childhood fall as early introduction becomes more common, new study finds

Scott Sicherer, MD, discusses research finding that after a major shift in guidance from delaying allergenic foods until 1 to 3 years of age to introducing them by 6 months of age, the prevalence of egg allergy among declined.

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Parents used to be advised to keep allergenic foods like eggs away from babies, especially if allergies ran in the family. But based on recent and evolving evidence, the advice is now almost the opposite – and new research suggests the shift in guidance is paying off.

06/05/2026

Researchers uncover a substantial component to

Behrang Mahjani, PhD, Veerle Bergink, MD, PhD, and Seulgi Jung, PhD, a postdoctoral fellow in the Mahjani Lab at Mount Sinai, discuss their research uncovering a substantial genetic component to postpartum psychosis, a rare but severe illness that occurs in the days to weeks after .

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Researchers at the Icahn School of Medicine at Mount Sinai have uncovered a substantial genetic component to postpartum psychosis, a rare but severe psychiatric illness that occurs in the days to weeks after childbirth. The findings, published in Molecular Psychiatry, provide new evidence that the c...

Address

1470 Madison Avenue
New York, NY
10029

Website

http://icahn.mssm.edu/research/institutes/child-health-and-development-institute

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Lauren Minchen Nutrition
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Dr. Paul Gregory, DDS
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