06/18/2026
This was a hard one to update in my own teaching. Metabolic stress was one of the three pillars of hypertrophy I learned in school. In Episode 5, Paul Carter walks through three consecutive studies that have killed the hypothesis. Lactate infusion in humans, mechanical overload in rodents, in vitro experiments with myotubes. No hypertrophic response in any of them. Metabolic stress was theorized but never proven, and the recent body of research has buried it. But academia hasn't caught up yet.
Full episode: https://www.youtube.com/watch?v=JNth7TPorSs