Journal of Experimental Medicine

Journal of Experimental Medicine The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research.

Since its inception in 1896, the goal of The Journal of Experimental Medicine (JEM) has been to publish outstanding and enduring studies in medical biology. At a time when many leading publishing groups are establishing topic-specific journals, we believe it is critical to complement that approach by offering a distinguished venue for publication of studies that integrate disciplines within the fi

eld of pathogenesis. A distinctive editorial system supports this goal with an emphasis on exceptional service to our authors. Two groups of editors work hand-in hand: professional editors with strong scientific backgrounds, and full-time practicing scientists. At least one editor from each group evaluates the merits of each paper prior to external review. The editors convene weekly to discuss all papers with external referee comments, and reach rapid decisions without excessive requests for revision. Within the field of medical biology we focus both on human studies and diverse in vivo experimental models of human disease that address such topics as genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We welcome reports ranging from atomic-level analyses to clinical interventions that illustrate new mechanisms.

Nakul M. Shah and Funda Meric-Bernstam (UT MD Anderson Cancer Center) review the rapidly evolving landscape of antibody–...
07/24/2026

Nakul M. Shah and Funda Meric-Bernstam (UT MD Anderson Cancer Center) review the rapidly evolving landscape of antibody–drug conjugates for . The authors evaluate major design components, clinical efficacy of approved agents, and determinants of response and resistance. https://hubs.la/Q04qFr6g0

07/22/2026

Lilian Salm, Monica Aida Lopez, Paul Kubes et al. (University of Calgary) reveal that peritoneal , activated by sensory neurons, extend that hand off extracellular condensate to neighboring , driving rapid aggregation & a repair phenotype. https://hubs.la/Q04qkmjT0

Insights: Wonseok Choi, Partha S. Biswas et al. (https://hubs.la/Q04q7Ysh0) identify a downstream tPA–LRP1 axis that saf...
07/21/2026

Insights: Wonseok Choi, Partha S. Biswas et al. (https://hubs.la/Q04q7Ysh0) identify a downstream tPA–LRP1 axis that safeguards the renal epithelium during systemic , revealing a mechanism by which IL-17 preserves organ integrity. Michail Lionakis highlights the findings: https://hubs.la/Q04q8r_q0

Wonseok Choi, Partha S. Biswas et al. show that tissue-type plasminogen activator protects against kidney damage, thereb...
07/21/2026

Wonseok Choi, Partha S. Biswas et al. show that tissue-type plasminogen activator protects against kidney damage, thereby highlighting a previously unrecognized tissue-protective signaling pathway that mitigates organ damage during . https://hubs.la/Q04q8sBP0

Conor Gruber, Dusan Bogunovic et al. (Columbia University Irving Medical Center) identify   mutations in a family with s...
07/16/2026

Conor Gruber, Dusan Bogunovic et al. (Columbia University Irving Medical Center) identify mutations in a family with severe early-onset pulmonary alveolar proteinosis (PAP), a rare lung disease marked by alveolar surfactant accumulation. https://hubs.la/Q04pM-t80

Our new   activity in collaboration with MSK CME is now available! ✍️💻  https://hubs.la/Q04pMW_80 New content 📄: “Famili...
07/16/2026

Our new activity in collaboration with MSK CME is now available! ✍️💻 https://hubs.la/Q04pMW_80

New content 📄: “Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2)” (Gruber et al. https://hubs.la/Q04pMYVM0)

What’s a Journal-Based CME activity? A full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment 👉 https://hubs.la/Q04pMW_80

📘 💡 Explore our special collection of recent research articles on the interface between the immune system and the enviro...
07/09/2026

📘 💡 Explore our special collection of recent research articles on the interface between the immune system and the environment at mucosal surfaces, timed to coincide with the Society for Mucosal Immunology's annual meeting in Montréal! 👉 https://hubs.la/Q04nVZ_j0

The collection covers a range of topics including aleveolar macrophage differentiation and function, fibroblast diversity in GALT, MAIT (dys)function after neonate antibiotic use, ILC3 homeostasis, gut immune tolerance by RORγt+ regulatory T cells, macrophage containment of melanoma, nasal and tonsillar humoral responses, and enteric nervous system rewiring during inflammation.

Rabia Nabi, Chien-Wei Lin, Yu Wang, Yi-Guang Chen et al. (Medical College of Wisconsin) show that both soluble & membran...
07/07/2026

Rabia Nabi, Chien-Wei Lin, Yu Wang, Yi-Guang Chen et al. (Medical College of Wisconsin) show that both soluble & membrane forms of CD137 expressed by Foxp3+ CD4 T cells are critical for immunoregulation, & they independently restrain development https://hubs.la/Q04nMJzT0


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Schroeder et al. from the Hui Hu lab (https://hubs.la/Q04nD2MJ0) report that the transcription factor BACH2 has context-...
07/06/2026

Schroeder et al. from the Hui Hu lab (https://hubs.la/Q04nD2MJ0) report that the transcription factor BACH2 has context-dependent dual functions in regulating the differentiation of follicular T helper cells. Jinfang Zhu (NIAID) discusses the findings: https://hubs.la/Q04nD52P0

IFNλ works at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang et al. (https://h...
07/06/2026

IFNλ works at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang et al. (https://hubs.la/Q04nD60v0) demonstrate that IFNλ also signals in kidney fibroblasts sustaining renal . Ivan Zanoni highlights the findings: https://hubs.la/Q04nDcdP0

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