Lexi Yoo, FNP, IFMCP, 9535 E 151th Street, Noblesville, IN (2026)

09/10/2026

I’m out of the office presenting at Aesthetic Next 8.0 in Dallas! 🎤✈️

If you’re here, this is where you’ll find me:

📍 September 10 | 2:30–3:00 PM
Building a Better Practice: The Blueprint for Integrating Wellness the Right Way

📍 September 10 | 3:45–4:45 PM
The Peptide Boom: Innovation Meets Regulation — Panel

📍 September 11 | 8:30–11:30 AM
Peptide Therapy Certification

📍 September 11 | 1:45–4:45 PM
Women’s Health & Hormone Replacement Therapy Certification

This is my fourth year presenting at Aesthetic Next, and I’m excited to share practical, evidence-based strategies you can actually take home and implement in your practice.

Will I see you at one of my sessions? Let me know which one! 👇🏼

09/10/2026

🧬 Your bloating didn’t start because your digestion got weaker. Here’s what actually changed.

As estrogen falls the microbiome shifts, beta-glucuronidase climbs, and more estrogen gets reabsorbed instead of leaving. That is a clearance problem showing up in your gut.

👉🏼 On a GI-MAP, elevated beta-glucuronidase reads three ways to me: dysbiosis or SIBO, an estrogen detox problem, or xenoestrogen exposure.

👉🏼 DIM and calcium-D-glucarate are not interchangeable. DIM changes how estrogen is metabolized and assumes you can already clear it well. When that assumption is wrong I see anxiety, headaches and fatigue. Calcium-D-glucarate works downstream on reabsorption, which is the one I want when constipation and bloating are the picture.

👉🏼 BPC-157 is studied for repair of the gut lining. KPV for calming inflammation in it. I use a combination capsule, 500 micrograms of each, one daily, after testing.

Order matters. Test, bowels moving daily, support the pathway, treat what you found, then repair.

💾 Save this for the next time your bloating gets blamed on food.

👇🏼 Comment KPV to get the link to the product I use with my patients.

⚠️ For educational purposes only. Not medical advice.

09/09/2026

🧠𝗦𝘁𝗿𝘂𝗴𝗴𝗹𝗶𝗻𝗴 𝘄𝗶𝘁𝗵 𝗽𝗿𝗼𝗴𝗲𝘀𝘁𝗲𝗿𝗼𝗻𝗲? 𝗔𝗻𝗼𝘁𝗵𝗲𝗿 𝗵𝗼𝗿𝗺𝗼𝗻𝗲 𝗺𝗮𝘆 𝗯𝗲 𝗽𝗮𝗿𝘁 𝗼𝗳 𝘁𝗵𝗲 𝗰𝗼𝗻𝘃𝗲𝗿𝘀𝗮𝘁𝗶𝗼𝗻.

It’s called prolactin.

➡️Prolactin is closely associated with lactation, but levels can also be influenced by factors like stress, thyroid function, B6, and dopamine.

📉When prolactin is elevated, it can interfere with ovulation or reduce progesterone production.

🌿That’s where an herb called chaste tree berry, also known as Vitex agnus-castus, comes into the conversation.

The idea discussed in the research is that Vitex may influence dopamine, which can suppress prolactin and potentially help get that signaling back on track.

The bigger lesson?

Hormones don’t work independently.

🔬𝗜𝗳 𝗽𝗿𝗼𝗴𝗲𝘀𝘁𝗲𝗿𝗼𝗻𝗲 𝗮𝗽𝗽𝗲𝗮𝗿𝘀 𝗹𝗼𝘄, 𝘀𝗶𝗺𝗽𝗹𝘆 𝗳𝗼𝗰𝘂𝘀𝗶𝗻𝗴 𝗼𝗻 𝗽𝗿𝗼𝗴𝗲𝘀𝘁𝗲𝗿𝗼𝗻𝗲 𝗺𝗮𝘆 𝗺𝗶𝘀𝘀 𝗼𝘁𝗵𝗲𝗿 𝗳𝗮𝗰𝘁𝗼𝗿𝘀 𝗶𝗻𝗳𝗹𝘂𝗲𝗻𝗰𝗶𝗻𝗴 𝘄𝗵𝘆 𝗶𝘁’𝘀 𝗹𝗼𝘄 𝗶𝗻 𝘁𝗵𝗲 𝗳𝗶𝗿𝘀𝘁 𝗽𝗹𝗮𝗰𝗲.

Sometimes understanding the upstream signal is just as important as looking at the hormone itself.

Controversial question: Are we too quick to replace hormones before investigating WHY they’ve changed?

Or are women wasting too much time trying supplements before considering hormones?

COMMENT 𝟭𝟭𝟱 TO GET THE EPISODE

09/09/2026

💪🏻 I’m 42, I’ve been on a GLP-1 for five years, and the things that kept my muscle on are honestly boring.

Nobody wants to hear it, because none of it is a hack. Muscle is your metabolic engine, and perimenopause is when women start losing it quietly. On a GLP-1 it is the first thing at risk when intake drops and the weight comes off fast. So here is what I actually do:

👉🏼 Protein at every meal
👉🏼 Strength training consistently
👉🏼 Creatine daily
👉🏼 I track lean mass, not just weight
👉🏼 I don’t chase the highest dose
👉🏼 I avoid chronic under-eating
👉🏼 I prioritize sleep and recovery

None of that is exciting. All of it is why the scale stopped telling the whole story for me. If you are losing weight and feeling weaker, you are not imagining it, and it is worth paying attention to before you go up another dose.

💾 Save this for your next appointment.

👇🏼 If you’re interested in learning more, comment BLUEPRINT to get a link to my roadmap on how to optimize your GLP-1 for longevity.

➕ Follow for the clinical side of this conversation.

⚠️ For educational purposes only. Not medical advice.

09/08/2026

💉 On September 17 the FDA discusses testosterone in women. Here is what I want you to understand.

Zero testosterone products are FDA approved for women. It is prescribed off label, from products dosed for men. The workshop decides what evidence an approval would need. Docket FDA-2026-N-5479.

Well, what about safety? Do we even have the research? Yes, we actually do. Not from studying women. From trans men, on higher doses, for longer, tracked in national registries.

👉🏼 1,229 trans men, median 15 years on testosterone: 4 invasive breast cancers, fewer than expected for cisgender women (de Blok, PMID 31088823).
👉🏼 293 patients on cross-sex hormones: mortality no higher than the general population, no serious morbidity from the androgen (van Kesteren, PMID 9373456).
👉🏼 7,837 trans men, 13 cohorts: 34 cardiovascular deaths, 1.81 per 1,000 person-years (Viana, PMID 41757239).

That review found zero cardiovascular deaths in 13 trials of 2,628 women, and grades the long term data low certainty.

💾 Save this for your next appointment.

👇🏼 Comment PERI if you would like to better understand your labs.
👇🏼 Comment HRT if you are a practitioner wanting to better understand the dosing nuances, clinical application, as well as patient monitoring.

⚠️ For educational purposes only. Not medical advice.

09/07/2026

💉 The battle of peptides continues. And what’s interesting is that not only does the FDA carry the influence, so do the state licensing boards. What prescribers should know:

👉🏼 Louisiana Act 374, effective 8/1/2026, passed 35-0 and 98-0. No licensing board there can punish a prescriber or pharmacist over peptides from a 503B outsourcing facility or a 503A pharmacy.

👉🏼 It did not legalize peptides. Federal law did not move.

👉🏼 Alabama went the other way. In May its board warned physicians that research grade peptides are prohibited for human use, and a signed consent form does not remove the provider’s liability.

👉🏼 The board that holds your license now matters as much as the agency does.

👉🏼 For patients it comes down to the source. What is in the vial, where it came from, who guides it.

💾 Save this for your next appointment.

👇🏻 If you’re interested in staying up to date with peptide news, be sure to hit the follow button.

👇🏻 If you’re interested in my breakdown of vetting your compounding pharmacy, comment SAFE to get the link.

⚠️ Peptides support the body, they do not heal it. For educational purposes only. Not medical advice.

09/07/2026

💊 Everyone talks about peptides for longevity. Almost no one talks about these ten, and none is FDA approved for it.

Six are FDA approved drugs used off label: naltrexone, methylene blue, pentosan polysulfate, rapamycin, tadalafil, telmisartan. Amlexanox was approved as a canker sore paste, then discontinued, so the oral form is compounded. 5-Amino-1MQ, larazotide and tesofensine were never approved at all.

Whether a molecule is approved tells you what evidence sits behind it, what dose is established, and whether the supply can disappear on you.

They group by what they do to aging:

👉🏻 Mitochondria. Methylene blue, 5-Amino-1MQ.
👉🏻 Inflammation. Pentosan polysulfate, low dose naltrexone, amlexanox.
👉🏻 Metabolic and vascular. Telmisartan, tadalafil, tesofensine.
👉🏻 Clearing and containing. Rapamycin, larazotide.

Most work upstream of the symptom, which is why one can turn up in conversations about joints, gut, mood and metabolism.

Every one needs a prescriber who knows your history.

💾 Save this for your next appointment.

👇🏻 If you’re a practitioner and interested in learning more on the exact protocol and dosing and how I implement these into practice, comment LABOR to get a link to my courses.

⚠️ For educational purposes only. Not medical advice.

09/07/2026

𝗙𝗲𝗲𝗹𝗶𝗻𝗴 𝗳𝗶𝗻𝗲 𝗱𝗼𝗲𝘀𝗻’𝘁 𝗮𝗹𝘄𝗮𝘆𝘀 𝗺𝗲𝗮𝗻 𝗲𝘃𝗲𝗿𝘆𝘁𝗵𝗶𝗻𝗴 𝗶𝘀 𝗳𝗶𝗻𝗲.

Some of the most important changes during perimenopause can happen quietly. 🫀

You can’t necessarily feel your blood sugar rising.

You may not notice your insulin moving into the double digits.

You can’t feel gradual bone loss.

And you may have no idea your blood pressure or cholesterol has changed. 🩸

That’s why perimenopause shouldn’t only be about managing the symptoms you can feel.

It’s also worth looking deeper and asking what’s actually changing inside the body. 🔬

Is it cortisol? Thyroid? Hormones? Iron deficiency? Cardiometabolic changes?

Sometimes you have to think like a detective: rule things out, rule things in, and look beyond symptoms alone. 🧩

You may have always thought of yourself as someone with “low blood pressure” or “low cholesterol”, but does that mean you should assume those numbers never change?

Here’s the bigger question: Should deeper cardiometabolic testing become a standard part of perimenopause care?

🎙️COMMENT 115 TO GET THE EPISODE

09/07/2026

💊 How well is your prescriber prepared for the estrogen patch shortage?

I cannot wait on a manufacturer. I can be fluent in every route, so my patients never miss a beat.

The shortage is downstream of a win.

👉🏼 November 10, 2025. The FDA moved to pull the boxed warning off menopausal hormone therapy.
👉🏼 February 12, 2026. New labels approved, dropping the cardiovascular, breast cancer and dementia statements.
👉🏼 More prescribers wrote it, more women asked, demand outran supply.
👉🏼 September 3, 2026. The FDA says patches remain available, but availability varies by pharmacy and brand.

An availability update is not a shortage declaration. One route is not a plan.

My toolbox:

👉🏼 Estradiol creams
👉🏼 Estradiol gels
👉🏼 Intravaginal estrogen
👉🏼 Estradiol injections
👉🏼 Estradiol pellets

The basic labs I start with: estradiol, progesterone, testosterone, SHBG, FSH and LH, full thyroid. I check far more. We check levels not just to manage symptoms, but to lower the risk of osteoporosis and other age related comorbidities.

💾 Save this for your next pharmacy run.

👇🏻 Comment LABOR for the YDH Academy Labor Day deal. Buy one course, get one free. Ends Tuesday, September 8, 8 a.m. ET. Prescribers, these routes are what I teach in the HRT Practice Accelerator.

⚠️ For educational purposes only. Not medical advice.

lexiyoonp

Lexi Yoo, FNP, IFMCP

09/10/2026

09/10/2026

09/09/2026

09/09/2026

09/08/2026

09/07/2026

09/07/2026

09/07/2026

09/07/2026

Address

Website

Alerts

Contact The Practice

Shortcuts

Share

Category

Listing takedown request