10/28/2026
Christina Applegate spent five years living with an MS diagnosis. This week she shared that she doesn’t have MS. Her symptoms haven’t gone anywhere. In her words, she’s back at square one.
I hear that phrase from women all the time.
She’s not an outlier. Research shared alongside her story found that nearly 1 in 5 people diagnosed with MS didn’t fully meet the criteria. There’s no single test for MS, and many of its symptoms show up in other conditions too.
Here’s the part that rarely comes up: menopause.
Fatigue. Brain fog. Poor sleep. Mood changes. Bladder issues. Those are MS symptoms. They’re also perimenopause symptoms.
About a third of women with MS are peri- or postmenopausal. One study found that women who reached menopause before their MS diagnosis waited longer for that diagnosis, close to 9 years on average compared with about 5.5. A 2026 review found that two-thirds of women with MS had never talked to a clinician about menopause at all.
It’s important to remember that our health is shaped by processes that unfold over time. Some are natural life stages, like perimenopause and menopause. Some are disease processes, like MS. At certain points, two very different processes can look almost the same. A single appointment captures one moment. Only data collected over time shows how things are actually changing.
That’s how misdiagnosis happens. Perimenopause and MS can be mistaken for each other, and the wrong label can lead to the wrong treatment.
That’s what Journal My Health is built for. Daily tracking turns “something’s off” into a timeline you can bring to your doctor. It doesn’t diagnose. It gives the conversation better information to work with.
It’s also why our research focuses on women managing chronic and autoimmune conditions through the hormonal transition.
Thank you to for discussing this with us.