Annals of Internal Medicine: Clinical Cases

Annals of Internal Medicine: Clinical Cases A partnership between the American College of Physicians and the American Heart Association, AIMCC i

A patient undergoing evaluation for plasma cell dyscrasia presented with hypercalcemia, lymphadenopathy, and skin findin...
08/28/2026

A patient undergoing evaluation for plasma cell dyscrasia presented with hypercalcemia, lymphadenopathy, and skin findings. Further investigation ultimately revealed sarcoidosis, underscoring the value of tissue biopsy in complex diagnostic cases. Read the full text for free: https://bit.ly/4wQaa8Q

Opioid-induced adrenal insufficiency and opioid-induced esophageal dysfunction, two complications of long-term opioid us...
08/27/2026

Opioid-induced adrenal insufficiency and opioid-induced esophageal dysfunction, two complications of long-term opioid use, remain underdiagnosed and poorly understood in routine clinical practice. A new case report describes a 64-year-old woman with chronic high-dose methadone use who developed secondary adrenal insufficiency with refractory hypotension and subsequently manifested with progressive esophageal dysfunction. Clinicians should maintain a high index of suspicion for endocrine and gastrointestinal complications in patients undergoing prolonged therapy. https://bit.ly/4wX8M4l

A rare fungal infection initially presented as pulmonary and subcutaneous nodules in an immunocompromised patient. Clini...
08/26/2026

A rare fungal infection initially presented as pulmonary and subcutaneous nodules in an immunocompromised patient. Clinicians in New Mexico ultimately diagnosed disseminated Emergomyces canadensis, a potentially fatal infection successfully treated with liposomal amphotericin B and posaconazole oral tablets. Read the case report for free here: https://bit.ly/4ghPXDY

A 55-year-old man with persistent hiccups and cough for more than 2 weeks were ultimately found to be manifestations of ...
08/26/2026

A 55-year-old man with persistent hiccups and cough for more than 2 weeks were ultimately found to be manifestations of a pulmonary embolism and deep venous thrombosis. This case report underscores why clinicians should avoid trivializing persistent hiccups when respiratory symptoms coexist. Read the full text for free: https://bit.ly/4gRHnvQ

Read online for free now: Successful Cryoablation of a Sacral Phosphaturic Mesenchymal Tumor Causing Tumor-Induced Osteo...
08/21/2026

Read online for free now: Successful Cryoablation of a Sacral Phosphaturic Mesenchymal Tumor Causing Tumor-Induced Osteomalacia https://bit.ly/4c4hOF5

Leprosy can mimic autoimmune and inflammatory diseases, making diagnosis challenging, especially in nonendemic settings....
08/20/2026

Leprosy can mimic autoimmune and inflammatory diseases, making diagnosis challenging, especially in nonendemic settings. A new image case report highlights the overlap between infectious and rheumatologic presentations where delayed recognition can occur. Read for free: https://bit.ly/4qtuj2P

A 28-year-old man with no family history of colorectal cancer or other concerning symptoms developed colocolonic intussu...
08/18/2026

A 28-year-old man with no family history of colorectal cancer or other concerning symptoms developed colocolonic intussusception, a condition rarely seen in adults where one part of the intestine slides inside another part. Tests showed that the intussusception was caused by poorly differentiated invasive mucinous adenocarcinoma of the colon. This case shows that cancer should be considered a possible cause of intussusception in adults, regardless of age or family history. https://bit.ly/3S0IoIx

Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially life-threatening inflammatory syndrome that can compl...
08/14/2026

Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially life-threatening inflammatory syndrome that can complicate systemic lupus erythematosus (SLE). A case report describes an uncommon presentation of developing HLH at the time of initial SLE diagnosis. Early recognition and immunosuppressive treatment resulted in clinical and biochemical resolution. Read for free: https://bit.ly/4bOSenz

A new case report describes a 50-year-old woman with renal papillary necrosis associated with sickle cell trait. After i...
08/13/2026

A new case report describes a 50-year-old woman with renal papillary necrosis associated with sickle cell trait. After inconclusive initial imaging, a CT urogram confirmed the diagnosis. This case underscores the importance of recognizing sickle cell trait as a potential cause of renal papillary necrosis and highlights key diagnostic and treatment considerations for clinicians. https://bit.ly/4wS3MPc

An outbreak of Vibrio vulnificus, a flesh-eating bacterium commonly found in warm water, has killed five people in Louis...
08/11/2026

An outbreak of Vibrio vulnificus, a flesh-eating bacterium commonly found in warm water, has killed five people in Louisiana. A recent case report details an immunosuppressed man who became infected with Vibrio vulnificus after sustaining a scratch from his dog, which had been swimming in warm coastal water.

Following surgery and antibiotics, the man recovered after 23 days. This case not only highlights an unconventional transmission route of Vibrio vulnificus, but it also emphasizes the importance of rapid diagnosis and treatment of high-risk patients. https://bit.ly/45Tiolo

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