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TGen TGen (Translational Genomics Research Institute) is a nonprofit biomedical research institute What is new and noteworthy in genomics?

What sorts of discoveries are coming from our laboratories in Phoenix, Scottsdale and Flagstaff, as well as our national and international collaborations? Find out by following us on this and all social channels:
- Twitter: https://twitter.com/TGen
- LinkedIn: https://www.linkedin.com/company/tgen

What if the key to fighting cancer and severe viral infections isn't just turning the immune system ON, but teaching it ...
10/22/2026

What if the key to fighting cancer and severe viral infections isn't just turning the immune system ON, but teaching it HOW to sense danger?

Henrique Borges da Silva, PhD, associate professor and co-director of the Immunology and Microbiome Division at TGen, broke down what a T-cell is and how danger sensing pathways are shaping the future of precision medicine.

Behind every medical breakthrough is an idea that needs support and encouragement. Before a treatment or diagnostic test...
10/21/2026

Behind every medical breakthrough is an idea that needs support and encouragement. Before a treatment or diagnostic test reaches a patient, it requires years of testing, specialized equipment, trained staff, and steady funding.

Here is the reality of scientific discovery:

1️⃣ Government funding has limits. Federal grants are essential, but competition is fierce. Highly valuable ideas and unconventional approaches are routinely left without funding simply because public budgets can't cover every promising project.
2️⃣ Early-stage ideas need seed money. Before researchers can qualify for massive federal grants, they need early proof and initial data.
3️⃣ Philanthropy bridges the gap. Donor support gives scientists the resources to test new ideas, chase unexpected discoveries, and build the foundation needed to secure larger grants later.

At TGen, part of City of Hope, our researchers are working to turn genomic discoveries into practical tools for cancer, neurological disorders, and rare diseases. Philanthropic gifts—of any size—provide the flexible, critical seed funding that keeps this precision medicine moving from the lab bench to the patients who need it most.

💡 Scientific progress doesn't move in a straight line, and donor support ensures it never stops moving forward.

➡️ Want to help bring the next breakthrough closer to patients? Learn how you can support life-changing research at TGen today at tgen.org

Improving cancer understanding and treatment starts at the lab bench. Dr. Sara Byron, research associate professor and c...
10/20/2026

Improving cancer understanding and treatment starts at the lab bench.

Dr. Sara Byron, research associate professor and co-director of the Bioinnovation and Genome Sciences Division at TGen , is passionate about using genomics to inform care for women with breast cancer. Her projects focus on using a cancer's unique genetic makeup to identify new therapeutic weaknesses within tumors, creating opportunities for more targeted and precise treatments.

A shopping spree that supports women's cancer research?!We've partnered with Veronica Beard to host a shopping event on ...
10/19/2026

A shopping spree that supports women's cancer research?!

We've partnered with Veronica Beard to host a shopping event on Thursday, Oct. 22, from 4- 6 p.m. A percentage of the proceeds will go to TGen in support of women's cancer research 🔬 💕

For this year's Breast Cancer Awareness Month, TGen and City of Hope Phoenix took a moment to thank and highlight our vo...
10/16/2026

For this year's Breast Cancer Awareness Month, TGen and City of Hope Phoenix took a moment to thank and highlight our volunteers who work tirelessly to raise awareness and support for women's cancer research 💕

Justine Hurry and Lee Courtney received "pink coats" as a token of gratitude and, of course, a pop of pink during October.

Scientists have found a new way to spot serious liver damage before it’s too late. Typically, doctors have had to use in...
10/15/2026

Scientists have found a new way to spot serious liver damage before it’s too late. Typically, doctors have had to use invasive biopsies to check for deep liver scarring. But researchers discovered 11 special proteins hidden inside tiny particles floating in our blood. As liver damage gets worse, the protein levels go up—making it easier to tell the difference between severe liver damage and full-blown cirrhosis. While it will take time to become a standard doctor’s office test, it's a huge step toward catching liver disease early and finding better treatments.

TGen City of Hope Johns Hopkins University

Thank you to all who made the sixth annual Runway for Research event a success. Thank you to our partners City of Hope P...
10/14/2026

Thank you to all who made the sixth annual Runway for Research event a success.

Thank you to our partners City of Hope Phoenix, Scottsdale Fashion Square, and Neiman Marcus Scottsdale.

Thank you to our incredible chairs Lee Courtney and Justine Hurry who worked tirelessly to bring the event, committee, and community together for this incredible cause.

To the Runway Committee – we are deeply grateful for all that you do to make the research at TGen possible, especially the funding of women’s cancer research.

This year’s event was inspired by the spirit, strength and momentum of the Year of the Horse, celebrating the determination to move research forward faster for women facing cancer. The fashion did not disappoint – with guests bringing their pink-inspired looks to life.

Thank you to all our speakers: Dr. Jeffrey Trent, Laurie Sicaeros, and Dr. Marnee Spierer for sharing your insights and vision for the future of womens cancer research and care.

Thanks to events like these, TGen and City of Hope Arizona are able to bring more personalized approaches to cancer treatment through the power of science and philanthropy.

Jenny Paredes, PhD, is not new to the research realm at TGen, we are thrilled to celebrate her appointment as an assista...
10/14/2026

Jenny Paredes, PhD, is not new to the research realm at TGen, we are thrilled to celebrate her appointment as an assistant professor in the Immunology and Microbiome Division and co-director of TGen's Integrated Microbiomics Center.

Dr. Paredes is a microbiologist whose research investigates how the microbiome, diet, and microbial metabolism shape immune responses and outcomes in cancer therapy. Her work spans tumor immunology, nutrition, and transplantation biology. By integrating clinical and dietary data with microbiome and metabolomic profiling, and mechanistic preclinical models, Dr. Paredes develops clinical, microbiome-directed interventions.

In addition to her leadership role at TGen, Dr. Paredes heads the microbiome team in the laboratory of Dr. Marcel van den Brink at City of Hope in Duarte, where she oversees multidisciplinary teams conducting clinical, computational, and experimental research.

Ever wonder why some people get cancer while others don't? A new study at City of Hope and TGen has found a big clue.Sci...
10/13/2026

Ever wonder why some people get cancer while others don't? A new study at City of Hope and TGen has found a big clue.

Scientists looked at healthy body parts and found something surprising: some healthy people have up to 8 times more gene mistakes (mutations) than others!

Why does this matter? Cancer develops as mutations accumulate in our DNA. Healthy people who naturally build up these mistakes much faster may therefore be much more likely to develop cancer later on.

Measuring a person's baseline mutation rate could help doctors identify people at higher risk and personalize cancer prevention and screening.

https://bit.ly/3UkrINa American Association for Cancer Research (AACR)

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