02/14/2026
The history of Naltrexone is beyond fascinating and interwoven with many contributors, some detractors and some very complex agendas.
In this Substack post shared by Joe Volpicelli, colleague Percy Mendez gives a compelling account and some answers to the question "How did we go from FDA approval of a scientifically sound way to treat the neurobiology of Alcohol Use Disorder (AUD) to a rather lackluster response from the community who was well-placed to embrace it?"
How naltrexone went from an FDA-approved failure to become a real-world tool.
