Great Earth Vitamin Store

08/29/2026

Researchers in Japan are actively developing and clinical-testing an experimental drug designed to regrow teeth, though it is not yet publicly available.

The Science Behind the Drug
Target Protein: The medicine (known as TRG-035) is an antibody treatment that targets a specific protein called USAG-1.

Dormant Buds: USAG-1 normally suppresses tooth growth. Researchers discovered that blocking this protein can reactivate dormant tooth buds—a hidden third set of potential teeth that humans and many mammals carry in their jaws but fail to develop naturally.

Animal Testing: Preclinical trials conducted on mice and ferrets successfully triggered the growth of new, fully functional teeth.

Current Status of Human Trials
Phase I Trials: Led by researchers from Kyoto University Hospital and the startup Toregem BioPharma, initial human safety trials began. These early tests focused primarily on safety and dosage in healthy adult participants rather than immediately verifying widespread regrowth.

Next Steps: Future trials aim to expand to young children with congenital tooth absence (anodontia), before eventually studying broader applications for adults who lost teeth due to injury or decay.

Expected Timeline: The research team hopes to make the treatment commercially available around 2030 if safety and effectiveness continue to clear clinical hurdles.

08/12/2026

I have been using melatonin for many, many years after discovering that melatonin helped to protect my brain.

I am now 81 years old and still have clarity of mind! 🤗

Far beyond its popular reputation as a simple "sleep hormone," melatonin is one of the central nervous system's most effective endogenous antioxidants and neuroprotective agents.

​What makes melatonin uniquely effective in the brain comes down to several distinct biochemical advantages:

​Crosses the Blood-Brain Barrier Effortlessly: Unlike many dietary antioxidants that struggle to enter brain tissue, melatonin easily crosses the blood-brain barrier and accumulates in higher concentrations within the central nervous system than in circulating blood.

​Produced Directly Inside Mitochondria: While the pineal gland releases melatonin into the bloodstream for sleep-wake signalling, neurons and glial cells synthesize melatonin locally inside their mitochondria. Because mitochondria generate the vast majority of cellular reactive oxygen species (ROS) during energy production, localized melatonin acts as an immediate, on-site scavenger.

​The "Antioxidant Cascade": Most classic antioxidants (like Vitamin C or E) neutralize a single free radical and are depleted. When melatonin neutralizes a free radical, its resulting metabolites (such as AFMK and AMK) also act as potent free-radical scavengers. A single melatonin molecule can initiate a multi-step cascade that neutralizes up to 10 reactive oxygen/nitrogen species.

​Upregulates the Brain's Internal Defenses: Beyond direct scavenging, melatonin signals brain cells to increase production of primary antioxidant enzymes like superoxide dismutase (SOD), catalase, and glutathione peroxidase, while helping recycle the body's chief antioxidant, glutathione.

​This night-time "clean-up crew" mechanism is one of the primary reasons chronic sleep deprivation or blue-light exposure before bed accelerates cognitive fatigue and long-term oxidative stress in the brain.

03/26/2026

Update, my shipping cost are going up! Bummer!

For the first time in its history, the USPS is introducing an 8% fuel surcharge on several shipping services starting April 26, 2026.

​The Postal Service announced this temporary increase on March 25, 2026, to offset soaring transportation and energy costs caused by market volatility.

Pending approval by the Postal Regulatory Commission, this surcharge is scheduled to remain in effect until January 17, 2027.

​Impacted Services
​The 8% surcharge applies only to "competitive" shipping products:
​Priority Mail Express
​Priority Mail
​USPS Ground Advantage
​Parcel Select

01/25/2026

Consider this:

Recent research suggests the shingles vaccine (Shingrix) may delay dementia onset, which is a significant marker of biological brain aging. While it doesn't stop the overall aging process, it appears to reduce neuroinflammation and potentially slow cognitive decline compared to other vaccines.

01/10/2026

Consider this, might be very important to some individuals!
Lp(a) can cause heart problems

Lipoprotein(a), or Lp(a), is a genetically determined fat particle that significantly increases the risk of heart attack and stroke. Research highlights three primary ways it damages your health:

​Atherogenic: It carries "bad" cholesterol that sticks to and clogs artery walls.

​Pro-thrombotic: It mimics blood-clotting proteins, making it harder for your body to dissolve clots.

​Pro-inflammatory: It irritates blood vessel linings, accelerating plaque buildup.

​Because Lp(a) levels are 90% genetic, diet and exercise rarely lower them. Current research is focused on breakthrough gene-silencing drugs (like Pelacarsen and Lepodisiran) that have shown the ability to reduce Lp(a) levels by up to 94% in clinical trials.

Results from major Phase 3 trials are expected later in 2025 and 2026 to confirm if these drugs successfully prevent heart events.

To help your doctor order the test, use the standard medical CPT code: 83695.

​If your doctor uses a specific laboratory, you can provide these lab codes:
​Quest Diagnostics: 34604 (Standard) or 91729 (Cardio IQ)
​Labcorp: 120188

​Since this test measures a genetic marker, insurance usually covers it when ordered for a family history of early heart disease.

01/01/2026

Happy New Year to all my friends and customers! I am sending my best wishes for 2026 to be kind to you. Enjoy your day, keep warm and be safe. Dennis

10/28/2025

I am using 10gms of Creatine twice a day (and sell it from Life Extension), and I have noticed a benefit! Consider this research, as published by Life Extension! I have also posted this on my website, greatearthvitaminstores.com. Enjoy your day and be safe. Dennis

A pilot trial resulted in improvements in cognition and increases in brain creatine levels among people with Alzheimer’s disease who consumed creatine monohydrate for eight weeks.

Creatine is an amino acid that is made in the body and occurs in seafood and meat. Creatine supports cellular energy, muscle strength, and other aspects of well-being, including brain health.
“Our data suggest that creatine monohydrate supplementation is feasible in Alzheimer’s disease and provides preliminary evidence for future efficacy and mechanism studies,” wrote authors Aaron N. Smith and colleagues, who reported the findings.

Total cognition, as well as fluid cognition, list sorting, working memory, and oral reading recognition, improved significantly by the end of the trial. Compared with the beginning of the trial, serum creatine was higher at four and eight weeks, and brain creatine significantly increased by 11%. “Although previous studies have demonstrated that creatine monohydrate...increases brain creatine in healthy individuals, our trial is the first to demonstrate this in Alzheimer’s disease,” the authors announced.

The current Creatine to Augment Bioenergetics in Alzheimer's (CABA) trial enrolled 20 men and women being treated for Alzheimer’s disease with drugs such as memantine or donepezil. Participants were instructed to consume 10 grams of creatine monohydrate twice per day for eight weeks. The creatine monohydrate used in the trial was donated by Life Extension Inc.

Tests that evaluated cognition were administered, and MRI scans that measured brain total creatine were performed at the beginning and end of the study. Serum creatine levels were measured before the treatment period and at four and eight weeks.
The trial findings were reported in the April-June 2025 issue of the Alzheimer’s Association journal Alzheimer's & Dementia: Translational Research & Clinical Interventions.

Great Earth Vitamin Store 68 Brooks Lane Sadler, Texas 76264 Phone: (972) 386-0803 Email: [email protected] Store Hours: Sunday through Saturday open at 10am Sunday through...

07/27/2025

Consider this, very important for longevity!

mTor
(mTOR) regulates cell proliferation, autophagy, and apoptosis by participating in multiple signaling pathways in the body. Studies have shown that the mTOR signaling pathway is also associated with cancer, arthritis, insulin resistance, osteoporosis, and other diseases.

As a major regulator of cell metabolism, mTOR signaling is at the forefront of autophagy regulation. Owing to the fact that nutrient availability and cellular stress modulate mTORC1 activity, mTORC1 is a consistent inhibitor of autophagy.

Autophagy
The science of autophagy is the science of cellular rejuventation. Through the advent of autophagy-enhancing therapies, we can trigger the cell's ability to recycle toxic misfolded proteins and debris to consume for energy, and revitalize a cell.

Why is autophagy important?

• Recycles damaged cell parts into fully functioning cell parts.

• Gets rid of nonfunctional cell parts that take up space and slow performance.

• Destroys pathogens in a cell that can damage it, like viruses and bacteria.

06/29/2025

Consider this and let me know if you have any questions.

mTor
(mTOR) regulates cell proliferation, autophagy, and apoptosis by participating in multiple signaling pathways in the body. Studies have shown that the mTOR signaling pathway is also associated with cancer, arthritis, insulin resistance, osteoporosis, and other diseases.

As a major regulator of cell metabolism, mTOR signaling is at the forefront of autophagy regulation. Owing to the fact that nutrient availability and cellular stress modulate mTORC1 activity, mTORC1 is a consistent inhibitor of autophagy.

Autophagy
The science of autophagy is the science of cellular rejuventation. Through the advent of autophagy-enhancing therapies, we can trigger the cell's ability to recycle toxic misfolded proteins and debris to consume for energy, and revitalize a cell.

Why is autophagy important?

• Recycles damaged cell parts into fully functioning cell parts.

• Gets rid of nonfunctional cell parts that take up space and slow performance.

Destroys pathogens in a cell that can damage it, like viruses and bacteria

05/11/2025

Consider this:

So, how do vitamin D3 and vitamin K2 work together in harmony? Vitamin D3 directs the absorption of calcium from your intestines into the blood. Vitamin K2 takes it from there, directing that calcium into your bones.

Think of it this way: calcium is like a baton, and vitamins D3 and K2 are like runners in a game of relay baton. Taken alone, both vitamins have multiple benefits, but to fully utilize and benefit from calcium, you should supplement with both vitamin D3 and K2.