05/29/2026
What Is NervEase Made Of?
NervEase contains five botanical ingredients in a proprietary blend. Here is a plain-language explanation of each and the role it plays.
Corydalis
Corydalis is the most pharmacologically distinctive ingredient. Its active alkaloid DHCB (dehydrocorybulbine) interacts with dopamine receptors involved in chronic pain processing rather than opioid receptors — which is why it carries no addiction risk. Chronic pain signal modulation is the precise mechanism most relevant to persistent sciatic discomfort. For more detail see our NervEase ingredients analysis.
Passion Flower
Passion Flower supports GABA-receptor activity in the brain. GABA is the primary inhibitory neurotransmitter that calms overactive neural signalling — the overactivity that produces tingling and burning in nerve pain. It also has established benefits for sleep quality and muscle relaxation, making it a multi-contributing ingredient in the formula.
Marshmallow Root
Marshmallow Root contributes anti-inflammatory and tissue-soothing effects through its mucilaginous compounds. It targets the inflammation pathway around the sciatic nerve root, complementing the more neurological pain mechanisms of the other ingredients with a tissue-level anti-inflammatory contribution.
Prickly Pear
Prickly Pear provides high concentrations of antioxidant flavonoids and betalains linked to reduced oxidative stress. Since oxidative damage is a recognised driver of nerve fibre and myelin sheath degradation over time, Prickly Pear addresses the long-term nerve protection dimension of the formula. This is the slowest-acting component and benefits most from months of consistent use.
California Poppy
California Poppy interacts with GABA receptors to provide mild analgesic and calming effects. Entirely unrelated to o***m poppy, it carries no addiction risk. It complements Passion Flower's GABA-supporting mechanism and rounds out the formula's approach to managing overactive nerve pain signalling.
Tags: