GenLight Technologies Personalized Genomics Medicine

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GenLight Technologies Personalized Genomics Medicine Personalized genomics-guided precision medicine for therapy-resistant prostate and breast cancers (h Long-term genomics-guided health management.

Genomics-guided personalized disease prevention, target-tailored precision medicine (http://genlighttechnology.com). Personalized genomics-guided precision medicine for therapy-resistant prostate and breast cancers (http://genlighttechnology.com). Inflammation & autoimmune disorders. Prostate, breast, and colon cancer risk assessment, diagnostic, prognostic, and therapy-selection services (http://genlighttechnology.com). Genlighttechnology provides unique, proprietary approach to consulting, diagnostics, and therapy-selection disease management and health maintenance services for individuals diagnosed with prostate & breast cancers. We provide these services to assist practicing physicians and cancer patients in decision-making process at the time of diagnosis of tumors in the prostate when the critical decision is made to select active surveillance ("watchful waiting") or aggressive therapeutic interventions with curative intent such as radical prostatectomy. Here is how it works.

1. You are diagnosed with prostate cancer. We will help to make a choice what treatment options to select. For many patients, it may be possible to determine before the treatment how likely is that initial therapy may fail and how soon cancer may come back after the treatment. This information will help to make a decision whether the individual patients are more or less likely to benefit from immediate or near-term therapeutic interventions. This is important because:

i) Treatment of prostate cancer is often associated with complications which significantly affect the quality of life of patients. These complications will adversely affect patients’ life to a greater extent than disease itself. ii) Most patients diagnosed with the early-stage prostate cancer will have clinically indolent disease. They typically have no clinical symptoms and disease will have no adverse effects of their well-being and quality of life. Therefore, these patients do not need immediate aggressive treatment because there will be no significant survival benefits from the treatment during their lifetime.

2. You already received treatment for prostate cancer. Your disease is in remission or you are “cancer-free”. For many patients, after the initial therapy was administered and they are "cancer-free'” with no clinical evidence of disease, we may be able help to determine the likelihood of therapy failure and disease relapse in the future. We may be able to determine how likely is that cancer may come back because patients have clinically latent residual disease and how soon it may progress to clinically lethal metastatic cancer. This is important because as early detection of primary tumors helps to increase the likelihood of cure, early detection of clinically latent residual disease may help to prevent the disease progression to metastatic, late-stage, lethal disease with no significant prospect of cure or choices of effective treatment options. We hope that this knowledge will help you, your family, and your doctors to make rational, evidence-based decisions on what steps to take and how to manage your life after being diagnosed with cancer.

Thyroid hormones, mitochondria, aging, and cancer.
09/01/2026

Thyroid hormones, mitochondria, aging, and cancer.

In mammals, thyroid hormones (THs) and their metabolites exert their regulatory effects on metabolism, oxygen consumption, energy generation and expenditure,...

Evidence-supported examples of default operations of protein-protein interactions  (PPI)-guided assemblies of hetero- an...
09/01/2026

Evidence-supported examples of default operations of protein-protein interactions (PPI)-guided assemblies of hetero- and homodimers of Yamanaka factors, neurogenesis constituents, and protein components of postsynaptic density of excitatory and inhibitory synaptogenesis are reported with detailed analytical focus on human Claustrum. The foundational set of observations reported in this contribution should facilitate experimental and theoretical explorations of transposable elements-seeded genomic codes for initiators of PPI chain reactions of protein dimerization creating pools of attractors to guide and accelerate the endogenous multiprotein complexes assemblies.

Mechanisms governing initiation steps of the assembly of endogenous multi-protein complexes (EMC) remain incompletely understood. Here, multiple lines of obs...

These observations point to a regulatory paradigm that small sets of highly-expressed genes that are significantly enric...
09/01/2026

These observations point to a regulatory paradigm that small sets of highly-expressed genes that are significantly enriched in distinct human brain regions are selected from genes encoding TFs bound to human-specific brain development regulatory regions, thus linking “neuroanatomical transcriptional signatures” of brain structures to TFs governing brain development. Together, our findings highlight TE-derived TFBS as central architects of primate brain evolution, providing both mechanistic insight and avenues for future discovery.

Transposable elements (TEs) have played a pivotal role in shaping the regulatory architecture of mammalian genomes. This contribution reports multiple lines of evidence suggesting that TE have made a significant impact on brain development by providing sequences for thousands of transcription factor...

Distinct panels of DNA-bound initiator TFs and proteins of PPI cascade ensembles are enriched in either defined sets of ...
08/29/2026

Distinct panels of DNA-bound initiator TFs and proteins of PPI cascade ensembles are enriched in either defined sets of neuroanatomical structures (TF-TF mode) or among structural-functional constituents of synapses (HUB proteins mode). Thus, these bifurcated cascades appear biologically congruent: TF–TF constituents map to transcriptional signatures of hundreds of brain regions, whereas HUB constituents map to synaptogenesis and synaptic structures, suggesting the unified logic of genomic functions coordinating region identity and connectivity.

Mechanisms governing initiation steps of the assembly of endogenous multi-protein complexes (EMC) remain incompletely understood. Here, multiple lines of obs...

Chromosome-naïve DNA scaffolds facilitating creation of intracellular dimer pools engage networks of ~700 transcription ...
08/29/2026

Chromosome-naïve DNA scaffolds facilitating creation of intracellular dimer pools engage networks of ~700 transcription factors (TFs), 534 of which manifest region-specific patterns of significantly enriched expression in 1358 brain regions. HAP initiators appear to operate within nucleosome-depleted islands of transposable elements (TE) – derived sequences within heterochromatin. PPI assembly lines of EMCs operate in 2 concurrent modes: TF-TF PPI cascade and PPI HUB protein cascade. Regardless of the number of DNA-bound initiator TFs (ranging from one to 716 TFs), both modes of operations reached the equilibrium at the PPI constituents saturation levels of ~245 proteins for TF-TF PPI modes and of ~351 proteins for PPI HUB protein modes.

Mechanisms governing initiation steps of the assembly of endogenous multi-protein complexes (EMC) remain incompletely understood. Here, multiple lines of obs...

Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retroviru...
08/29/2026

Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans.

Timelines of population-level effects of viruses on humans varied from the evolutionary scale of million years to contemporary spread of viral infections. Correspondingly, these events are exemplified by: (i) emergence of human endogenous retroviruses (HERVs) from ancient germline infections leading...

Transposable Elements Seed Transcription Factor Binding Sites to Sequence-Specific Double-Stranded DNA Binding TF Networ...
08/29/2026

Transposable Elements Seed Transcription Factor Binding Sites to Sequence-Specific Double-Stranded DNA Binding TF Networks Contributing to Governance of Primate Brain Evolution.

Transposable elements (TEs) have played a pivotal role in shaping the regulatory architecture of mammalian genomes. This contribution reports multiple lines of evidence suggesting that TE have made a significant impact on brain development by providing sequences for thousands of transcription factor...

Initiators of hybrid assembly pathways of endogenous multiprotein complexes appear to operate within nucleosome-depleted...
08/27/2026

Initiators of hybrid assembly pathways of endogenous multiprotein complexes appear to operate within nucleosome-depleted islands of transposable elements (TE) – derived sequences within heterochromatin. PPI assembly lines of EMCs operate in 2 concurrent modes: TF-TF PPI cascade and PPI HUB protein cascade. Regardless of the number of DNA-bound initiator TFs (ranging from one to 716 TFs), both modes of operations reached the equilibrium at the PPI constituents saturation levels of ~245 proteins for TF-TF PPI modes and of ~351 proteins for PPI HUB protein modes.

Mechanisms governing initiation steps of the assembly of endogenous multi-protein complexes (EMC) remain incompletely understood. Here, multiple lines of obs...

The molecular anatomy of hybrid assembly pathways of multiprotein complexes was elucidated by defining qualitative and q...
08/24/2026

The molecular anatomy of hybrid assembly pathways of multiprotein complexes was elucidated by defining qualitative and quantitative characteristics of protein binding to a compendium of 200,393 distinct genomic regulatory elements (GRE), including 49,667 sequences representing control sets of genomic loci as well as 150,726 GRE of different evolutionary origins.

Mechanisms governing initiation steps of the assembly of endogenous multi-protein complexes (EMC) remain incompletely understood. Here, multiple lines of obs...

Genome-wide, chromosome-naïve compartmentalization of major developmental networks tailored by modular placement of huma...
08/23/2026

Genome-wide, chromosome-naïve compartmentalization of major developmental networks tailored by modular placement of human embryo-regulatory Long Terminal Repeats.

At inception, eukaryotes solved the conflict of the physical dimensions of meter-sized linear chromatin fibers placed into micron-sized nuclei by employing two mechanisms: (i) fragmenting genomic DNA into sets of shorter segments, called chromosomes;

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