10/05/2026
October is Down Syndrome Awareness Month—and we're spotlighting research that could change outcomes for families.
Nearly half of all babies born with Down syndrome face congenital heart defects serious enough to need surgery in their first months of life.
In this video, Deepak Srivastava, Katie Pollard, and Sanjeev Ranade explain how our team used stem cells, gene editing, and AI to pinpoint the gene driving these heart defects — and how dialing down its activity in mice restored normal heart development.
It's early-stage work, but it points toward future treatments that could help prevent these malformations before they start.
In this video, Gladstone scientists share how they used stem cells, gene editing, and AI to identify a gene driving heart defects in Down syndrome—and how reducing its levels in mice restored normal heart development, offering hope for future treatments