10/14/2026
Some people have tried three antidepressants. Five. Seven. And still haven’t found meaningful relief.
That’s treatment-resistant depression (TRD), and an estimated 4 million Americans are living with it. Today, for the first time, it has its own awareness day.
We’re proud to join Compass Pathways and leading advocacy organizations in marking .
Across the Osmind community, we see what’s possible when people with TRD reach clinicians who specialize in interventional treatment. Earlier this year, we helped define “interventional psychiatry” in Nature Mental Health, because shared language is how a field grows and how more patients find their way to it.
Awareness is the first step. Earlier recognition is the next. Our mission is to help clinicians bring evidence-based treatments to the patients who need them most.
If you or someone you love is living with TRD, you are not alone.