10/01/2026
A major new review is sparking conversation about IVF add-ons and the evidence behind them. Researchers examined 10 commonly used IVF add-ons, including PGT-A, endometrial receptivity testing, corticosteroids, EmbryoGlue, endometrial scratching, PICSI, PRP, acupuncture and intralipid infusions. Of 157 potentially eligible trials assessed for trustworthiness, 72 were excluded for concerns such as lack of prospective trial registration. Ultimately, 85 randomized controlled trials were included.
The takeaway isn't that every add-on is ineffective. Most are not currently proven to improve outcomes for patients undergoing IVF. For some, research suggests little to no benefit. For others, the evidence is still too limited or uncertain to know.
There were some signals worth further study. Endometrial scratching was associated with a small possible increase in live birth, while PICSI was associated with fewer miscarriages, although its effect on live birth remains uncertain.
At the UCSF Center for Reproductive Health, we follow the evidence. We don't recommend add-ons simply because they're new or popular. We consider the quality of the research, the outcomes that matter to patients, and whether there is credible evidence that an intervention may help.
Fertility care is also individualized. If you're curious about an IVF add-on, talk with your fertility doctor about what the evidence shows, what remains uncertain, and what may be appropriate for you.