05/29/2026
Lyme disease is not a single clinical picture, and treating it as one is where most approaches fall short.
In the early stages, the infection itself is often the primary driver. But as the illness progresses, the infection becomes less of the story, and immune dysregulation becomes more of it. What was triggered by Borrelia may now be sustained by a dysregulated immune system that has lost its ability to regulate itself, shaped by individual biology, pre-existing vulnerabilities, and how long the body has been in that state.
This distinction matters for how these patients are evaluated and treated.
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