04/28/2026
Skin Cancer 3/4
Treatment:
Cryotherapy/Electrocautery
For Actinic Keratosis, there are a couple of options. For small areas, cryotherapy (freezing) or electrocautery can kill affected cells and stop progression. However, this only works for small, visible areas.
Topical Chemotherapy
A common treatment for AK’s, very early BCC, and SCC is a topical chemotherapy called Efudex. Efudex targets abnormal precancerous and cancerous cells and kills them by affecting the cells' DNA. The abnormal cells are destroyed while leaving most healthy cells untouched.
Efudex is a topical lotion applied daily to the targeted areas for approximately 4 weeks. Important to note that treatment times can vary. As the medication is targeting the abnormal cells, you will start to notice some changes. The first week of treatment, there might be some redness, tingling, or irritation. The second week will generally bring more pronounced redness, areas of sun damage that are “lit up”, burning, and even some open sores. While difficult to experience, this is exactly the response we are looking for. This is where Efudex performs a little miracle, revealing hidden damage to the skin that the naked eye cannot see. Week three is where things start to get tough. Your skin is bright red, inflamed, and painful, with small erosions (open sores) that may be crusted or scabbed. This is when the abnormal cells are being destroyed. It is not uncommon for certain areas of the skin to become inflamed and sore more quickly than others. This indicates that these areas have faster cell turnover, meaning they are more significant areas of concern. That brings us to week four, the final week of treatment in most cases. It is common to still have crusty, patchy areas and open sores. You might start to see the inflammation decrease and healing begin.
The unique feature of Efudex is that even when the treatment is stopped, it continues to work. However, in the first few weeks after treatment stops, you will notice that your skin starts to heal, the redness fades to pink, and the inflammation, irritation, and pain slowly subside. Your skin is returning to its normal state. I can’t emphasize enough how important sunscreen is during the treatment, healing, and post-treatment phase. Your skin is very vulnerable during this treatment and will be especially vulnerable to the sun.
After healing, it is important to assess your skin closely. Looking for any patchy, red, inflamed areas that remain after treatment. These may need to be biopsied and treated accordingly.