08/13/2026
The National Cancer Institute’s Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis program provides R01 funding for clinical research evaluating new or improved approaches to cancer diagnosis and treatment.
The National Cancer Institute (NCI) has established two program announcements for R01 applications to support investigator-initiated clinical trials that are now reissued as:
1. PAR-25-081 (this Notice of Funding Opportunity), which seeks applications for support of early phase (Phase 0, I, and II) medical imaging and oncologic interventional clinical trials relevant to the mission of the NCI's Division of Cancer Treatment and Diagnosis (DCTD); and Office of HIV and AIDS Malignancies (OHAM); and
2. PAR-25-167 (companion Notice of Funding Opportunity), which seeks applications for support of cancer prevention and control clinical trials relevant to the missions of NCI's Division of Cancer Prevention (DCP) and NCI's Division of Cancer Control and Population Sciences (DCCPS), respectively.
Applicants should be aware of the types of scientific programs that each named NCI Division manages to determine the appropriate NOFO defined above for submission of applications.
Eligibility Criteria:
Public and private institutions of higher education are eligible.
Eligible state, local, tribal, and federal government organizations may apply.
Foreign/non-U.S. organizations are eligible.
Organizations may submit more than one application provided the proposals are scientifically distinct.
New, renewal, resubmission, and revision applications are permitted.
Cost sharing or matching funds are not required.
Funding Details:
Maximum budget: $499,999 in direct costs per year.
Maximum project period: 5 years.
Therefore, a project funded at the maximum annual amount for five years could receive up to $2,499,995 in direct costs.
The number of awards is not predetermined and depends on NIH appropriations and the number of meritorious applications.
Grant Amount: Up to $2,499,995 in direct costs over 5 years
Read the information on submission requirements at:
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: National Cancer Institute's Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis (R01 Clinical Trial Required) PAR-25-081. NCI