Regenerative & Hormone Medicine

Regenerative & Hormone Medicine RHM provides expert, physician-led care via nationwide telemedicine.

We look beyond the numbers to uncover the root cause of your symptoms, delivering personalized regenerative care to restore hormone balance and support your long-term health.

08/14/2026

The dangers of stopping TRT cold turkey. 👆🏼

(Speaker: Dr. Rand McClain, Founder & D.O. of Regenerative & Hormone Medicine)

Alcohol is one of the most overlooked variables in hormone health. Most patients are surprised to learn how quickly and ...
08/13/2026

Alcohol is one of the most overlooked variables in hormone health. Most patients are surprised to learn how quickly and how consistently their drinks show up in their labs.

A 2024 meta-analysis published in Andrology, examining chronic alcohol consumption and the gonadal axis in men, found significant reductions in total testosterone, free testosterone, and s*x hormone binding globulin, alongside an increase in estradiol. That increase in estradiol reflects enhanced aromatization, the process by which testosterone gets converted into estrogen. In women, alcohol has similarly been shown to increase circulating estrogens across menstrual and postmenopausal phases.

None of this means you can never drink. It means that if you are trying to optimize energy, recovery, body composition, mood, or libido, the amount you drink is not a separate wellness topic, it is upstream of your hormone panel. At RHM, we ask about alcohol early, because the answers matter for how quickly you can actually feel better.

Start at rhmmed.com.

Source: Santi D et al. (2024). The Chronic Alcohol Consumption Influences the Gonadal Axis in Men: Results from a Meta-Analysis. Andrology.

By the time your fasting glucose or HbA1c is abnormal, your metabolic health may have been quietly deteriorating for yea...
08/10/2026

By the time your fasting glucose or HbA1c is abnormal, your metabolic health may have been quietly deteriorating for years. Insulin resistance is one of the earliest signals we have, and it is almost never measured in standard primary care.

A 2025 analysis of the STOP DIABETES cohort, published in the Journal of Clinical Endocrinology and Metabolism, examined 624 nonobese adults with normal fasting glucose and normal HbA1c and found that roughly one in four were already insulin resistant. That resistance was associated with multiple markers of dysglycemia and cardiometabolic risk. In other words, patients who look perfectly healthy on a standard lab panel can already be on a metabolic trajectory that will not become obvious for years.

At RHM, fasting insulin is part of our standard metabolic evaluation because it tells us what fasting glucose alone cannot. We look at the metabolic system as a system, not one number at a time.

Start at rhmmed.com.

Source: Armato JP et al. Pre-Prediabetes: Insulin Resistance Is Associated With Cardiometabolic Risk in Nonobese Patients (STOP DIABETES). (2025) Journal of Clinical Endocrinology and Metabolism.

08/07/2026

The problem with overdoing TRT. ❌

(Speaker: Dr. Rand McClain, Founder & D.O. of Regenerative & Hormone Medicine)

The public conversation about GLP-1 medications has been dominated by weight loss. The published data tells a bigger sto...
08/03/2026

The public conversation about GLP-1 medications has been dominated by weight loss. The published data tells a bigger story. A 2025 prespecified analysis of the SELECT trial, published in The Lancet, examined how baseline body size and weight loss magnitude related to cardiovascular outcomes in more than 17,000 patients.

The finding: about two-thirds of the reduction in major adverse cardiovascular events was not explained by weight loss at all. The cardioprotective effect of semaglutide was largely independent of baseline adiposity and how much weight patients lost during treatment. That reframes GLP-1s from weight loss agents to cardiometabolic medications with broad effects on inflammation, blood pressure, glucose handling, and vascular biology.

At RHM, GLP-1s are used with full lab monitoring, protein and strength training to protect lean mass, and a plan that treats the metabolic system, not just the mirror.

Start at rhmmed.com.

Source: Deanfield J et al. (2025). Semaglutide and Cardiovascular Outcomes by Baseline and Changes in Adiposity Measurements: A Prespecified Analysis of the SELECT Trial. The Lancet.

07/31/2026

Does testosterone cause sleep apnea? Here’s the truth. 👆🏼

(Speaker: Dr. Rand McClain, Founder & D.O. of Regenerative & Hormone Medicine)

The 20-year story about HRT and cardiovascular risk is finally getting the full context it deserved. A 2025 secondary an...
07/30/2026

The 20-year story about HRT and cardiovascular risk is finally getting the full context it deserved. A 2025 secondary analysis of the Women’s Health Initiative, published in JAMA Internal Medicine, examined more than 27,000 postmenopausal women, focusing specifically on those experiencing moderate to severe vasomotor symptoms.

For women aged 50 to 59, hormone therapy had neutral effects on atherosclerotic cardiovascular disease and reduced hot flashes by roughly 41 percent. For women 60 to 69, the risk profile was more nuanced. For women 70 and older, the authors urged caution. Age at initiation and time since menopause are not footnotes. They are central variables in whether HRT is appropriate for a specific patient.

At RHM, hormone therapy is never a blanket recommendation. It is a careful, individualized decision based on your age, symptoms, labs, family history, and goals.

Start at rhmmed.com.

Source: Rossouw JE et al. Menopausal Hormone Therapy and Cardiovascular Diseases in Women With Vasomotor Symptoms: A Secondary Analysis of the Women’s Health Initiative Randomized Clinical Trials. (2025). JAMA Internal Medicine.

The most quietly dismissed symptom of the menopause transition is what happens to cognition. Brain fog, word-finding gap...
07/27/2026

The most quietly dismissed symptom of the menopause transition is what happens to cognition. Brain fog, word-finding gaps, executive-function slowdowns. Many women are told it is stress, sleep, or just aging. Imaging says otherwise.

In a 2024 study published in Scientific Reports, researchers used PET imaging with a tracer that binds directly to estrogen receptors and scanned the brains of 54 women aged 40 to 65. Brain estrogen receptor density changed measurably across the menopause transition, with a pattern consistent enough to predict menopause status with 100 percent accuracy based on four key brain regions. Estrogen is not just a reproductive hormone, it is a neurologic one, woven into the systems that regulate memory, mood, sleep, and thinking.

At RHM, midlife cognitive symptoms are evaluated as biology, not personality. We look at hormones, sleep, metabolism, and recovery together, and we build care that reflects what your body and your brain are actually experiencing.

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Source: Mosconi L et al. (2024). In Vivo Brain Estrogen Receptor Density by Neuroendocrine Aging and Relationships with Cognition and Symptomatology. Scientific Reports.

07/24/2026

Is it possible to gain muscle without eating carbs?

👉 Book your free VIP consult via the link in bio.

(Speaker: Dr. Rand McClain, Founder & D.O. of Regenerative & Hormone Medicine)

Hashimoto's thyroiditis is one of the most common autoimmune conditions in the country, and it is one of the most narrow...
07/23/2026

Hashimoto's thyroiditis is one of the most common autoimmune conditions in the country, and it is one of the most narrowly treated. Because standard care often focuses only on TSH and thyroid hormone replacement, many patients continue to feel unwell despite technically “normal” labs.

Hashimoto's is autoimmune, which means it is not just a thyroid problem. The immune system, inflammation, thyroid signaling, and broader metabolic health all interact. Fatigue that does not improve with rest, brain fog, weight changes, hair thinning, low motivation, and bloating are common because so many systems are affected at once. A 2014 review in Autoimmunity Reviews summarized the clinical and diagnostic complexity, and how much broader the picture is than a single lab value.

At RHM, Hashimoto's is evaluated in context. Full thyroid panel, antibodies, inflammation, metabolism, and recovery. Care is individualized and monitored over time.

👉 Book your free VIP consult via the link in bio.

Source: Caturegli P, De Remigis A, Rose NR. Hashimoto Thyroiditis: Clinical and Diagnostic Criteria. (2014). Autoimmunity Reviews.

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Santa Mon, CA

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