In 1991, the John Wayne Cancer Institute (JWCI) launched a successful affiliation with Saint John’s Health Center and opened in Santa Monica, California. Combined with the exceptional quality of Saint John’s Health Center and expertise of their medical staff, the John Wayne Cancer Institute was renamed on January 1, 2021 to Saint John’s Cancer Institute (SJCI). SJCI, renowned for its strength in oncology research, genomic sequencing, and science-based collaboration, offers exception support in the areas of surgical oncology, immunotherapy, chemotherapy, and radiation therapy. SJCI conducts multidisciplinary basic, clinical, and translational research for complex cancers, focusing particular on melanoma, breast, prostate, colon, neuroendocrine, gastro-intestinal, and sarcoma. With renowned researchers and advanced technologies, Saint John’s Cancer Institute has the unique ability to respond, explore, and investigate life-saving cancer treatments quickly and effectively. Developed at the Institute, the Sentinel Node Biopsy is one such innovation. Now considered the worldwide standard of care for melanoma and breast cancer, the Sentinel Node Biopsy has revolutionized treatment options by offering a minimally invasive technique to determine the spread of tumor cells. The Donald L. Morton Complex General Surgical Oncology Fellowship (formerly the John Wayne Cancer Institute Complex General Surgical Oncology Fellowship) was developed to train and educate world-class surgeons, who through their research and dedication, find solutions to complex cancer cases that remain unsolved. Recognized as one of 35 accredited training programs in the United States and Canada approved by the Society of Surgical Oncology, SJCI’s fellowship program has trained over 150 surgical oncologists and remains a leader in surgical oncology education. Learn more at https://www.saintjohnscancer.org/