05/15/2018
Alzheimer's disease is a degenerative disease in which a substance called amyloid infiltrates the brain and the brain fills with neurofibrillary tangles. It is not an infectious disease. It accounts for the greatest percentage of dementia, a decrease in memory and in brain function. Years ago, before Alzheimer's was recognized as such a common illness, older people with loss of mental function were said to have hardened arteries. Some people with dementia do have hardened arteries, but it's a much smaller number than used to be thought, and it comes nowhere near the number of cases of Alzheimer's disease. Many of the new treatments in development have the potential to be the first disease-altering medication for this disease. One, for example, uses immunotherapy, an antibody treatment aimed to directly attack the disease and prevent it from progressing. Another possible treatment uses antibodies to significantly reduce the level of amyloid-β, a protein found in the brains of people with early-onset Alzheimer’s.
Researchers are also testing treatments that target tau protein tangles that damage and kill brain cells, as well as a receptor that decreases a neurotransmitter necessary for the brain to think and function normally. Additionally, there are medicines being designed to decrease inflammation found in the brains of Alzheimer’s patients while strengthening the immune system to fight the disease. If just one of these treatments is proven effective, can possibly delay this disease by five years, reducing the number of people affected by roughly 40 percent. The war against Alzheimer’s might be far from over, but patients finally have hope for the future. And for good reason. With all the emerging advancements coming forward, now have more promising treatments than ever before. One of which might just defeat this deadly disease entirely. For all of us.