09/14/2026
WHY GENETICS MATTER: A DEEP DIVE INTO MTR 🧬
MTR is the gene that helps make methionine synthase, an enzyme that plays a key role in the methylation cycle. Methylation is a critical process that's part of your Phase 2 Detoxification.
Think of MTR as the worker that helps convert homocysteine back into methionine. This process requires vitamin B12.
Why does that matter?
Methionine helps produce SAMe, one of the body’s major methyl donors. Methylation is involved in neurotransmitter metabolism, DNA regulation, hormone metabolism, and more.
And there’s another piece of the puzzle: MTRR helps recycle B12 so MTR can keep doing its job.
However, Having an MTR variant does NOT automatically mean your methylation is broken or that you need more B12.
I look at MTR alongside MTHFR, MTRR, COMT, CBS and other pathways, plus labs like homocysteine, B12, folate and MMA when appropriate.