08/21/2026
Not all weight loss medications are created equal, and picking the right one isn't as simple as choosing whatever's trending.
In this episode, Lisa Oldson, MD walks through the framework she uses in her practice to decide which weight loss medication is right for each patient. She starts with other health conditions like sleep apnea, heart disease, diabetes, migraines, and fatty liver disease, then moves through safety considerations, cost, and how much weight loss someone actually needs. Whether someone prefers a shot or a pill is always a consideration.
Using a real patient case, Dr. Lisa breaks down how GLP-1 medications like Zepbound (tirzepatide) and Wegovy (semaglutide), and other meds (like Qsymia and Foundayo) get matched to the right person. She also explains why medication for excess weight is legitimate, evidence-based chronic disease treatment, and not "cheating." This medication episode wouldn't be complete without an update on retatrutide, the "Triple G," next-generation medication making headlines with over 28% weight loss in recent trials. Listen now!