06/19/2026
Substance P is significantly elevated in patients with fibromyalgia. Research shows that levels of this neurotransmitter can be two to three times higher than normal in the cerebrospinal fluid (CSF) of individuals with the condition.
Fibromyalgia is a syndrome characterized by chronic widespread musculoskeletal pain, which may or may not be associated with muscle or joint stiffness, accompanied by other symptoms such as fatigue, sleep disturbances, anxiety, and depression. It is ...