10/01/2026
ME/CFS AND ASD: ARE WE ASKING THE RIGHT MEDICAL QUESTIONS?
For decades, patients with what is now called ME/CFS — many of them women — struggled to have their illness taken seriously. Today, we know much more.
ME/CFS is recognized as a serious, multisystem illness. In many patients, symptoms begin after an infection, and research continues to examine abnormalities involving the immune system and other biological pathways.
So why is this important to families dealing with ASD?
Because I believe there is an important lesson here.
When a previously healthy person becomes chronically ill following an infection, we should investigate the biology.
And when a previously developing child changes — losing language, energy, attention, motor abilities, social engagement or other previously acquired skills — we should also be asking: What happened medically?
Not every child with an ASD diagnosis has the same underlying condition. A behavioral label should not end the medical investigation.
For years, I have argued that a subset of children diagnosed with ASD may have an underlying complex immune/complex viral or other medical disorder producing autistic-like symptoms.
That hypothesis should be tested with good science — not dismissed simply because the child has already been given a diagnostic label.
ME/CFS taught medicine an important lesson: patients with complex chronic illness deserve serious biological investigation. Children deserve the same curiosity.
We need better research into infection (particularly chronic viral), immune dysfunction, inflammation, neurological function and other measurable medical abnormalities — and we need treatments based on what the science actually demonstrates.
The diagnosis should be the beginning of the investigation, not the end.
Dr. Michael Goldberg, M.D.
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