08/22/2026
This problem is getting worse.
Call us, please.
Kratom-related reports to U.S. poison centers have exploded by more than 65-fold — and severe medical outcomes have risen alongside them.
A national analysis published in Addiction examined kratom exposures reported to U.S. poison centers between 2010 and 2023. Researchers found just 19 reported exposures in 2010, compared with 1,242 in 2023 — roughly a 6,500% surge.
The increase wasn't limited to the number of reports. In 2010, no severe outcomes were recorded. By 2023, 158 cases involved life-threatening effects, significant lasting disability, or death.
Across the entire study period, researchers analyzed 8,919 kratom-related exposures, and about 13% were classified as having a severe medical outcome.
Kratom comes from Mitragyna speciosa, a tree native to Southeast Asia. Its active compounds can produce stimulant-like effects at lower doses and opioid-like effects at higher doses. Researchers are particularly concerned about interactions with other substances, since kratom compounds may interfere with enzymes involved in drug metabolism.
The study also found that states where kratom sales were banned had significantly lower rates of reported exposures, severe outcomes, hospitalization, and healthcare use than states without bans. However, because the research was observational, it cannot prove that the bans themselves caused those lower rates.
One important distinction: these figures represent cases reported to poison centers, not the total number of Americans using kratom.
Source: Comstock, G., Gulotta, A. P., Rein, L. E., & Feldman, R. (2026). Association between state-level kratom regulations and poison center-reported severe medical outcomes and healthcare use: A United States national analysis. Addiction. DOI: 10.1111/add.70416.
As kratom becomes more widely available, should it remain largely regulated at the state level — or is stronger nationwide oversight needed?