07/02/2026
A new large retrospective study published in Investigative Ophthalmology & Visual Science raises an important question about commonly prescribed calcium channel blockers and glaucoma progression.
Researchers reviewed electronic health record data from more than 7,400 patients with mild to moderate primary open angle glaucoma. After matching patients for factors such as age, s*x, race, ethnicity, and hypertension, they found that patients taking calcium channel blockers had a higher rate of progression to severe glaucoma compared with similar patients not taking these medications.
The association was seen with both major types of calcium channel blockers. Dihydropyridine calcium channel blockers were linked to a 67 percent higher relative risk of progression, while nondihydropyridine calcium channel blockers were associated with more than a threefold higher risk.
This does not prove that these medications cause glaucoma to worsen. The study had important limitations, including reliance on diagnosis codes and lack of detailed eye pressure, visual field, medication adherence, and treatment duration data.
The take home message is not to stop blood pressure or heart medications. These medications can be very important and should only be changed after discussion with the prescribing doctor or cardiologist.
However, for patients with glaucoma who are taking calcium channel blockers, this study suggests they may benefit from closer monitoring for signs of progression.
Medical education only. This is not personal medical advice.