The New England Journal of Medicine

The New England Journal of Medicine The New England Journal of Medicine (NEJM.org) is the world's leading medical journal and website.

A 60-year-old woman with stage II triple-negative breast cancer presented to the ED with a weeklong history of fevers, r...
08/11/2026

A 60-year-old woman with stage II triple-negative breast cancer presented to the ED with a weeklong history of fevers, rigors, malaise, nonproductive cough, and nausea.

A 60-year-old man presented with a 1-month history of postprandial epigastric pain. CT of the abdomen showed a diffusely...
08/10/2026

A 60-year-old man presented with a 1-month history of postprandial epigastric pain. CT of the abdomen showed a diffusely enlarged pancreas with a capsule-like rim. Serum levels of IgG4 were elevated.

A new Perspective in NEJM AI examines the impact of AI on national health care expenditures, arguing that near-term cost...
08/09/2026

A new Perspective in NEJM AI examines the impact of AI on national health care expenditures, arguing that near-term cost reductions will depend heavily on policy and management choices rather than the technology alone.

In the latest NEJM Voices blog post, Dr. Paul Sax explains why his dog, Archie, gets concerned every time he tries to ac...
08/08/2026

In the latest NEJM Voices blog post, Dr. Paul Sax explains why his dog, Archie, gets concerned every time he tries to access a patient’s medical record when he’s not in the hospital.

A new Clinical Practice article summarizes the classification, evaluation, risk stratification, and management of syncop...
08/08/2026

A new Clinical Practice article summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients.

For years, medicine offered clinicians a well-defined path: medical school, residency, fellowship, and into practice.Tod...
08/07/2026

For years, medicine offered clinicians a well-defined path: medical school, residency, fellowship, and into practice.

Today, clinicians have greater flexibility to shape careers around what matters most to them—whether that's clinical time, research, leadership, identity, or purpose.

Join NEJM Clinician for its upcoming event to explore how clinicians can move from following an externally defined path to intentionally designing a career that evolves with their goals, strengths, and priorities.

Learn more and register for this free virtual event: https://nej.md/4fSkhmW

A 61-year-old man with prolonged neutropenia as a result of salvage chemotherapy for acute myeloid leukemia was evaluate...
08/07/2026

A 61-year-old man with prolonged neutropenia as a result of salvage chemotherapy for acute myeloid leukemia was evaluated on hospital day 37 for persistent neutropenic fever despite treatment with broad-spectrum antimicrobial agents. Physical exam was notable for a lesion with central necrosis on the chest and a similar lesion on the left palm. A serum 1,3-β-D-glucan level was elevated, and a galactomannan was negative. Computed tomography of the chest, abdomen, and pelvis was performed. Gram’s staining of blood culture revealed septate, hyaline hyphae. What is the most likely causative organism?

Leishmaniasis is a parasitic infection that is transmitted by sand flies and caused by multiple leishmania species, with...
08/06/2026

Leishmaniasis is a parasitic infection that is transmitted by sand flies and caused by multiple leishmania species, with different species capable of causing cutaneous, visceral, or mucosal forms of the disease.

A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination...
08/05/2026

A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a pulsatile liver (shown in a video).

08/04/2026

This video in our partnership with Dr. Glaucomflecken explains a head-to-head trial comparing rituximab versus ocrelizumab in newly diagnosed relapsing multiple sclerosis.

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