09/07/2026
On a daily basis I get questions from patients asking if they should get the shingles vaccine.
I just send them these study results and have them make an informed decision.
A 2025 paper in Clinical Infectious Diseases (Shetty AN, et al. Transient Increased Risk of Shingles Post-Shingrix Vaccination: Self-Controlled Case-Series Analysis) looked at real-world data after Shingrix (recombinant zoster vaccine) rollout.
In the primary-care dataset, adults 65 and older had an 11-fold increase in shingles presentations in the first 21 days after dose 1 (relative incidence 10.96; 95% CI 10.34–11.62). That signal was not seen in younger adults
Read it yourself and decide with your own clinician what makes sense for you:
https://academic.oup.com/cid/article/81/5/e446/8250066
That’s the data I share.
No pressure either way — just the information so you can weigh it.