RNA Therapeutics Institute

10/15/2026

Hot off the press from the RTI: Nucleic acid therapeutics in neurodegenerative disorders: emerging technologies and clinical landscape
https://buff.ly/n5gxw1N

Neurodegenerative disorders have diverse etiologies from monogenic mechanisms such as toxic gain-of-function mutation in subsets of amyotrophic lateral sclerosis (ALS) to multifactorial cascades exemplified by Alzheimer's disease (AD), which feature proteostasis failure, neuroinflammation, mitochond...

10/14/2026

Hot off the press from the RTI: Ex vivo machine perfusion enables robust and widespread lipophilic-conjugated siRNA delivery to the porcine lung
https://buff.ly/I6azxKs

Normothermic EVLP enables widespread delivery and cellular uptake of fully chemically modified, DCA-conjugated siRNA in donor lungs during clinically relevant perfusion times. These findings establish proof-of-concept for EVLP as a controlled platform for ex vivo delivery of programmable oligonucleo...

10/11/2026

Kicking off with Rebecca Miles, co-chairs Julia Alterman & Aurelie Goyenvalle, and Anastasia Khvorova’s introduction of keynote speaker Tom Cech!

10/11/2026

Hot off the press from the RTI: Fanconi anemia pathway disruption drives lomustine sensitivity in glioma
https://buff.ly/4byyj9G

Together, these findings identify FA pathway components as key synthetic lethal interactors of CCNU response and reveal a therapeutically actionable vulnerability in glioblastoma.

10/07/2026

Hot off the press from the RTI: Population genetics, trait mapping and fungal pathogen surveillance using untargeted sequencing in timber rattlesnakes (Crotalus horridus)
https://buff.ly/K3ewZ2T

Genomic tools are increasingly important for conservation and wildlife health surveillance, yet their use is often constrained by limited resources, sample quality, and the need for minimally invasive approaches. Here we show that untargeted low-coverage sequencing applied to scale-clip DNA can join...

10/05/2026

Hot off the press from the Watts & Khvorova labs: Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system https://buff.ly/FUvJ0hf

10/01/2026

Hot off the press from the Korostelev lab: Assay for ribosome stimulation of angiogenin nuclease activity
https://buff.ly/jzn5Tuh

Angiogenin (RNase 5) is an unusual member of the RNase A family with very weak RNase activity and a preference for tRNA. The tRNAs cleaved by angiogenin are thought to have a variety of roles in cellular processes including translation reprogramming, apoptosis, angiogenesis, and neuroprotection. We....

09/09/2026

Welcome back from the summer, we hope you're ready for the new school year! See all the updates in the RTI Messenger:
https://buff.ly/DzhfV9X

09/06/2026

Hot off the press from the RTI: In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles

https://buff.ly/2oBzymV

09/03/2026

Congrats to the Awardees of the 2026 Michael R. Green, MD, PhD, Award in Graduate Research, Andrew Petti (RTI; Wen Xue's Lab) and Brennon Berard (MCCB; Dohoon Kim's Lab). Save the Date for their research presentations: Tuesday Sept 8, 2026 at 11:00am DiMare Center, N1-1500