01/07/2026
ADHD is often viewed as a neurotransmitter disorder, but genetics tells a much bigger story.
Many individuals with ADHD also have increased oxidative stress, nutrient depletion, mitochondrial dysfunction, glutamate imbalance, and chronic nervous system activation. Supporting dopamine alone is rarely enough when the brain also needs the nutrients required to produce energy, recycle neurotransmitters, and protect neurons.
Key nutrients like vitamin C, magnesium, niacinamide (B3), and riboflavin (B2) play essential roles in neurotransmitter metabolism, mitochondrial function, antioxidant defense, and nervous system regulation. Additional nutrients such as glycine, taurine, P5P, L-theanine, zinc, phosphatidylserine, choline, acetyl-L-carnitine, CoQ10, and creatine may be appropriate depending on an individual's genetics and physiology.
Genes including COMT, DRD2, DAT1, MAOA, BDNF, GAD1, MTHFR, MTRR, SHMT1, SLC6A4, DAO, and HNMT help explain why no two people with ADHD present the same—or respond to the same support.
There is no universal ADHD protocol. The goal is to understand the biology driving the symptoms and support those pathways first.
The Nutrigenomics Clinical Database helps practitioners quickly explore these genes, associated pathways, nutrient interactions, and clinical considerations to make more informed, personalized decisions.