02/08/2026
"Cognitive decline represents one of the most feared consequences of aging—not simply because of memory loss, but because it erodes identity, independence, and the essence of self. While Alzheimer’s disease and related dementias are often framed as inevitable consequences of aging, a growing body of evidence challenges this deterministic view. Cognitive decline is not a singular disease process but rather the culmination of multiple interacting biological insults: metabolic dysfunction, vascular injury, chronic inflammation, mitochondrial failure, oxidative stress, and impaired proteostasis."
Preventing Cognitive Decline: A Multi-Axis, Systems-Based Approach