07/08/2026
Serotonin in your gut is less like a volume dial and more like a communication network.
Specialised cells in the intestinal lining can release serotonin in response to signals such as stretch, nutrients and microbial metabolites.
But release is only the beginning.
What happens next depends on:
â which receptor receives the signal
â where that receptor is located
â how nearby nerves and cells respond
â how quickly SERT helps clear the serotonin
This is why IBS cannot be reduced to having âtoo muchâ or âtoo littleâ serotonin.
Research suggests that different parts of this signalling system may be altered in IBS, but the pattern is not identical in every person or IBS subtype. Serotonin may influence motility, secretion and visceral sensation, but it is only one part of a much larger picture.
Understanding the physiology can help symptoms feel less mysterious. During a flare, however, you also need practical steps.
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