09/08/2026
New article on one of the most important but under-discussed mechanisms in neurobiology: the link between gut permeability and the kynurenine pathway.
When the intestinal barrier becomes more permeable, inflammatory signals like LPS can enter circulation, activate immune pathways, and shift tryptophan metabolism toward neuroactive and sometimes neurotoxic kynurenine metabolites.
That matters for mood, cognition, pain, neuroinflammation, liver load, and the progression of neurological disorders.
In the article, I explore:
• how gut permeability influences the kynurenine pathway,
• whether LPS is involved, and why it often is,
• which microbial patterns may contribute,
• why the liver is central to the process,
• how brain inflammation and neurotransmitter balance are affected,
• and what other systems, including the immune system, blood-brain barrier, vagus nerve, and mitochondria, should be considered.
If you are interested in the gut-brain axis, neuroinflammation, depression, Parkinson’s disease, Alzheimer’s disease, chronic pain, or the microbiome’s role in neurological health, this is a topic worth reading closely.
Read the article here: https://www.nutrunity.com/updates/gut-permeability-the-kynurenine-pathway-and-neurological-disease