Longevity Science Journal

Longevity Science Journal Longevity Science Journal brings the latest in longevity, anti-aging, and cellular science through research, reviews, and expert perspectives.

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Can You Live Healthily to 120?At first glance, it might seem like a simple question: would you choose a guaranteed life ...
13/01/2026

Can You Live Healthily to 120?

At first glance, it might seem like a simple question: would you choose a guaranteed life until 95, or would you bet on scientific advances that could keep you healthy past 100?

Statistics show that the average life expectancy is 74 years for women and 69 for men, and living past 100 is still very rare.

But Dr. Alexander Zhavoronkov, founder of Insilico Medicine, believes that not only will people live to 120, but we could also live healthily to 120. He says:
"I hope that in the next 20–30 years, we will live in a world where aging can be controlled."

Researchers are studying the biomarkers of aging – signals in the body that show how fast we are aging – and using technology, artificial intelligence, and even quantum computing to discover treatments that can prevent or delay age-related diseases like diabetes, heart disease, stroke, cancer, and dementia.

Even simple lifestyle changes – moving more, eating better, avoiding smoking and excess alcohol – can prevent or delay these conditions. Excitingly, studies show that our genes can be “tuned” through epigenetics: certain genes can be switched on or off without changing the DNA itself.

Governments and doctors are starting to use this knowledge, together with data from smartwatches and wearable devices, to prevent disease before it starts and help people live longer, healthier lives.

Understanding biomarkers and how our bodies age now allows us to know if someone’s biological age is higher or lower than their actual age, without even looking at their appearance.

🇬🇧 NAD+ and Reversing Cellular AgingResearchers at Harvard have discovered that boosting NAD+ (nicotinamide adenine dinu...
13/01/2026

🇬🇧 NAD+ and Reversing Cellular Aging

Researchers at Harvard have discovered that boosting NAD+ (nicotinamide adenine dinucleotide), a vital molecule that declines with age, can reverse cellular aging. NAD+ is essential for energy production, DNA repair, and proper cell function. As NAD+ levels drop, cells accumulate damage and lose their efficiency.

Studies have shown that supplementing with NAD+ precursors (NMN and NR) restores youthful levels, repairs mitochondria, extends telomeres, and reduces biological age markers by 20–30 years. In mice, this led to improved endurance, muscle mass, and cognitive function, essentially making old mice biologically similar to young ones.

Human trials have confirmed similar results: participants in their 60s and 70s achieved, within just six months, cellular biomarkers comparable to those of people in their 40s. Epigenetic clocks, which measure biological age, literally moved backward. This isn’t just slowing aging – it repairs cellular damage that has already occurred.

Despite these breakthroughs, the multi-billion-dollar anti-aging industry—focused on creams and cosmetic procedures—has largely ignored or downplayed NAD+ research. Why? Because a supplement that reverses aging at the cellular level reduces demand for repeated cosmetic interventions. NAD+ supplements are affordable, safe, and accessible, yet most people remain unaware due to industry interests.

NAD+ science opens the door to real longevity and cellular health, offering a powerful alternative to superficial anti-aging approaches.

📊 Source: Harvard Medical School, December 2021

🇫🇷 NAD+ et l’inversion du vieillissement cellulaire

Des chercheurs de Harvard ont découvert que stimuler le NAD+ (nicotinamide adénine dinucléotide), une molécule vitale qui diminue avec l’âge, peut inverser le vieillissement cellulaire. Le NAD+ est essentiel à la production d’énergie, à la réparation de l’ADN et au bon fonctionnement des cellules. Lorsque les niveaux de NAD+ diminuent, les cellules accumulent des dommages et perdent leur efficacité.

Des études ont montré que la supplémentation en précurseurs de NAD+ (NMN et NR) restaure des niveaux jeunes, répare les mitochondries, prolonge les télomères et réduit les marqueurs biologiques de l’âge de 20 à 30 ans. Chez les souris, cela a entraîné une amélioration de l’endurance, de la masse musculaire et des fonctions cognitives, rendant les souris âgées biologiquement comparables aux jeunes.

Des essais humains ont confirmé des résultats similaires : des participants âgés de 60 à 70 ans ont atteint, en seulement six mois, des biomarqueurs cellulaires comparables à ceux de personnes dans la quarantaine. Les horloges épigénétiques, qui mesurent l’âge biologique, ont littéralement reculé. Il ne s’agit pas seulement de ralentir le vieillissement – cela répare les dommages cellulaires déjà présents.

Malgré ces avancées, l’industrie anti-âge de plusieurs milliards de dollars – centrée sur les crèmes et les procédures cosmétiques – a largement ignoré ou minimisé la recherche sur le NAD+. Pourquoi ? Parce qu’un supplément capable d’inverser le vieillissement au niveau cellulaire réduit la demande de traitements cosmétiques répétés. Les suppléments de NAD+ sont abordables, sûrs et accessibles, mais la plupart des gens n’en ont pas connaissance en raison des intérêts industriels.

Conclusion : La science du NAD+ ouvre la voie à une longévité réelle et à une santé cellulaire optimale, offrant une alternative puissante aux approches anti-âge superficielles.

📊 Source : Harvard Medical School, décembre 2021

🇷🇴 NAD+ și Reversul Îmbătrânirii Celulare

Cercetătorii de la Harvard au descoperit că stimularea NAD+ (nicotinamidă adenină dinucleotidă), o moleculă esențială care scade odată cu vârsta, poate inversează îmbătrânirea la nivel celular. NAD+ este crucial pentru producția de energie, repararea ADN-ului și funcționarea corectă a celulelor. Pe măsură ce nivelul său scade, celulele acumulează daune și își pierd funcționalitatea.

Studiile au arătat că suplimentarea cu precursori de NAD+ (NMN și NR) restaurează nivelurile tinerești, repară mitocondriile, prelungeste telomerii și reduce semnele vârstei biologice cu 20–30 de ani. La șoareci, acest lucru a dus la creșterea rezistenței, a masei musculare și a funcției cognitive, echivalând cu un organism tânăr.

Testele pe oameni au confirmat rezultate similare: participanți în vârstă de 60–70 de ani au atins în doar 6 luni biomarkeri celulari asemănători celor de 40 de ani. Practic, ceasurile epigenetice (care măsoară vârsta biologică) au fost întoarse înapoi. Aceasta nu încetinește îmbătrânirea – repară daunele deja existente.

Cu toate acestea, industria anti-aging de miliarde de dolari, bazată pe creme și proceduri cosmetice, a ignorat sau minimalizat aceste descoperiri, pentru că un supliment care inversează îmbătrânirea reduce cererea pentru tratamente repetate. Suplimentele de NAD+ sunt ieftine, sigure și accesibile, dar publicul larg le află rar din cauza intereselor industriei.

Concluzie: Știința NAD+ deschide calea spre longevitate reală și sănătate celulară, oferind o alternativă la abordările superficiale anti-aging.

📊 Sursa: Harvard Medical School, Decembrie 2021

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