10/06/2026
In 2024, two independent studies triggered a wave of alarmist content across social media claiming creatine is dangerous for women with endometriosis. Here's what those studies actually showed — and what they didn't.
The first, published in Advanced Science (Chen et al., 2024), found that creatine may help ectopic endometrial stromal cells resist a form of cell death called ferroptosis, potentially allowing lesions to persist. The authors themselves acknowledged that results were obtained from in vitro cell cultures and mouse models, and that findings need to be further verified using additional clinical and animal studies. The second, published in Reproduction (2025), examined macrophage behaviour in a lab setting. Its findings were also based on in vitro experiments — not on women taking oral creatine supplements.
Neither study measured symptom progression in humans. Neither involved oral supplementation. Translating petri dish findings into clinical advice is not science — it's content.
Creatine is synthesised in the body from arginine, glycine, and methionine in the kidneys, liver, and pancreas. For those who need support without supplementing creatine directly, working with its precursors through targeted nutrition is a viable, evidence-informed approach.
📩 DM 'health' on Instagram .tzanis for science-based support with autoimmune and hormonal health.
Studies referenced:
Chen et al. (2024). Creatine promotes endometriosis by inducing ferroptosis resistance via suppression of PrP. Advanced Science, 11, e2403517. DOI: 10.1002/advs.202403517
Feng et al. (2025). Creatine promotes endometriosis progression by inducing M2 polarization of peritoneal macrophages. Reproduction, 169(3). DOI: 10.1530/REP-24-0278