Anastasis Tzanis

Anastasis Tzanis Reversing the Toll of Autoimmune and Heart Stress Without the Cycle of Endless Meds (for women 40+).

From Greece to New York to London, I served in the Greek Special Forces as a paratrooper for 1-year, traded currency derivatives in New York and then London for 7 years and picked up a couple of other dopamine-driven hobbies along the way! During my time working in banking, I noticed how detrimental stress can be on our bodies – leading to stiffness, early ageing, and injury, which led me to begin

studying yoga & nutritional therapy in 2009. You can read more at: https://www.atzanis.com/about-anastasis-tzanis/

10/06/2026

Perfect cholesterol numbers, low triglycerides, clean LDL, his doctor sent him home with a handshake. But his heart was pounding, and a comprehensive serum lipids test revealed bottomed-out leptin levels.

Low leptin doesn't just mean low body fat — it signals metabolic exhaustion, and research warns it may predict cardiovascular mortality through increased cardiac cell death.

You aren't shredded. Your body is in biological red line.

For educational purposes only.

10/06/2026

In 2024, two independent studies triggered a wave of alarmist content across social media claiming creatine is dangerous for women with endometriosis. Here's what those studies actually showed — and what they didn't.

The first, published in Advanced Science (Chen et al., 2024), found that creatine may help ectopic endometrial stromal cells resist a form of cell death called ferroptosis, potentially allowing lesions to persist. The authors themselves acknowledged that results were obtained from in vitro cell cultures and mouse models, and that findings need to be further verified using additional clinical and animal studies. The second, published in Reproduction (2025), examined macrophage behaviour in a lab setting. Its findings were also based on in vitro experiments — not on women taking oral creatine supplements.

Neither study measured symptom progression in humans. Neither involved oral supplementation. Translating petri dish findings into clinical advice is not science — it's content.

Creatine is synthesised in the body from arginine, glycine, and methionine in the kidneys, liver, and pancreas. For those who need support without supplementing creatine directly, working with its precursors through targeted nutrition is a viable, evidence-informed approach.

📩 DM 'health' on Instagram .tzanis for science-based support with autoimmune and hormonal health.

Studies referenced:
Chen et al. (2024). Creatine promotes endometriosis by inducing ferroptosis resistance via suppression of PrP. Advanced Science, 11, e2403517. DOI: 10.1002/advs.202403517

Feng et al. (2025). Creatine promotes endometriosis progression by inducing M2 polarization of peritoneal macrophages. Reproduction, 169(3). DOI: 10.1530/REP-24-0278

09/06/2026

Harvard researchers tracking nearly 190,000 people across decades kept finding the same thing they couldn't explain: people who ate more ice cream appeared to have a lower risk of developing type 2 diabetes — a condition that frequently co-occurs with autoimmune disorders.

A 2002 JAMA study by Harvard's Dr Mark Pereira, following over 5,000 adults, found that dairy-based desserts — primarily ice cream — were associated with a 2.5x greater risk reduction for insulin resistance syndrome than milk or cheese alone. A later Harvard doctoral thesis extended this, finding that people with type 2 diabetes who ate half a cup of ice cream daily showed a decreased risk of cardiovascular problems — with the researchers themselves noting there were "few plausible biological explanations."

The key detail: this applies to dairy-based ice cream. This challenges the assumption that a "clean," often dairy-free diet is automatically the healthier path. Metabolic resilience isn't about restriction — it's about educating your gut flora and metabolism to handle real food.

📩 DM 'health' on Instagram .tzanis to find out more.

Studies referenced:
Pereira et al. (2002). Dairy consumption, obesity, and the insulin resistance syndrome in young adults: The CARDIA Study. JAMA, 287(16), 2081–2089. DOI: 10.1001/jama.287.16.2081

Your immune system doesn't malfunction randomly. In most cases, there's a structural reason — and it starts at the genet...
08/06/2026

Your immune system doesn't malfunction randomly. In most cases, there's a structural reason — and it starts at the genetic level.
Variants in PTPN22, HLA-DQ/DR, MTHFR and IRF5 are among the most studied genetic risk factors for autoimmune disease. Research confirms these aren't passive markers — they actively influence immune tolerance, inflammatory signalling, and cellular regulation. (Gregersen et al., 2005 | Oda et al., 2015 | Zhu et al., 2019)

🧬 What makes this clinically relevant is that gene expression is not fixed.

Targeted nutritional intervention — omega-3 fatty acids, methylfolate, Sedum sarmentosum, and Vitamin D — has demonstrated measurable effects on the pathways these variants dysregulate.

ʏᴏᴜʀ ɢᴇɴᴇs ᴀʀᴇ ɴᴏᴛ ᴀ ᴅɪᴀɢɴᴏsɪs.
ᴛʜᴇʏ ᴀʀᴇ ᴀ ᴄʟɪɴɪᴄᴀʟ ʀᴏᴀᴅᴍᴀᴘ.

💬 DM me "GENE" to find out how your diet and lifestyle can put your autoimmune disease into remission.

07/06/2026

Historically, fertility was viewed strictly as a female responsibility, but it takes two to tango. With global s***m counts dropping significantly, men are finally stepping up.

Before trying to conceive, a man should follow a two-stage approach: establish a healthy medical baseline, and then optimize for conception. Here is the data backing why it's time to talk about male fertility:

📉 S***m Counts are Plummeting: A landmark meta-analysis shows that global s***m counts have plummeted by over 60% in recent decades, driven by lifestyle, environmental factors, and poor health baselines.

Study: Andrology (2023) highlights this drastic decline and underscores the critical need for paternal preconception awareness.

👶 The Preconception Impact: A man's health directly impacts the success of a pregnancy and the future health of the child. Yet, studies show more than half of men take zero action to improve their health before trying to conceive.

Study: Plymouth Electronic Archive and Research Library (PEARL) found that while male health dramatically impacts the embryo, 57% of men made no preconception lifestyle changes.

😮‍💨 Breathing Affects Testosterone: The way you breathe—especially at night—dictates your hormone levels. Mouth breathing and sleep-disordered breathing fragment REM sleep and cause drops in oxygen, which directly suppresses testosterone production.

Study: Andrology confirms that breathing obstructions during sleep disrupt circadian hormone rhythms, drastically slashing serum testosterone levels.

📥 Ready to take control of your fertility? DM me "HEALTH" on Instagram for a personalized lifestyle and supplement plan.

07/06/2026

The go-to female fertility supplements aren’t as perfect as you think. Here is the real science behind them:

💊 CoQ10 is pricey. While it improves egg quality, exercise can naturally boost mitochondrial function and reduce oxidative stress just as effectively.

Study: Journal of Assisted Reproduction and Genetics shows CoQ10 benefits, while Frontiers in Endocrinology confirms exercise enhances mitochondrial health.

🧠 Choline + Omega-3s belong together. This combo is a powerhouse for fetal brain development and placental function.

Study: The American Journal of Clinical Nutrition highlights that combining choline and DHA significantly enhances nutrient uptake and brain health.

☀️ Vitamin D3 isn’t a blanket fix. Essential if you are deficient, but excess intake without a deficiency can negatively impact reproductive hormones.

Study: Nutrients confirms Vit D’s role in fertility, but warns of a “U-shaped curve” where toxicity harms reproductive outcomes.

⚠️ The Folate Trap. High folate without B12 and B2 causes “methyl trapping,” hiding a B12 deficiency and potentially causing neurological damage or pregnancy complications.

Study: The Journal of Nutrition outlines how excess folic acid masks B12 deficiency and disrupts the methylation cycle.

📥 Want a personalized plan? DM me “HEALTH” on Instagram to achieve your goals through tailored supplement, diet, and lifestyle interventions.

05/06/2026

Most people are completely brainwashed by traditional nutrition advice, clinging to theories that just don't work in reality. We’ve been told for decades that a high-fiber, "clean" diet is the absolute gold standard for staying regular, yet millions of people eating this exact way still find themselves completely backed up and struggling.

When your diet rules aren't matching up with your actual body's results, it's time to stop making excuses for the theories and start looking at what truly triggers healthy digestion.

Ever look at a supplement label and feel like you’re reading a foreign language? 😵‍💫If you are trying to optimise your n...
03/06/2026

Ever look at a supplement label and feel like you’re reading a foreign language? 😵‍💫

If you are trying to optimise your nervous system, mistaking L-Threonine for L-Threonate (or vice versa) means you might be targeting your muscles when you meant to target your brain!

🧠 L-Threonate has a "backstage pass" to the brain. Because it crosses the blood-brain barrier seamlessly, it is the ultimate tool for banishing brain fog, quietening a racing mind, and improving deep sleep quality (Li et al., 2014; Mito Health, 2026).

💪 L-Threonine is the structural workhorse. As an essential amino acid, it creates calming chemicals that halt muscle twitching, protect your nerve pathways, and support physical recovery (Barbeau et al., 1982; Roufs, 1991).

⚡ Not sure which form your body is asking for right now? DM me on Instagram for personalised advice on how to balance your nervous system. ⚡

Stop guessing with your supplements. Target the right system, get the right results. 👇

03/06/2026

We treat oxygen as good and carbon dioxide as bad, but that's exactly the wrong way to think about breathing.

Your cells can't actually use oxygen without carbon dioxide working alongside it.

The right breathing exercises intentionally elevate CO2 at specific heart rate zones, and that's what trains your body to use oxygen more efficiently.

For educational purposes only.

ʏᴏᴜʀ ᴍᴇᴛᴀʙᴏʟɪꜱᴍ ɪꜱɴ'ᴛ ᴊᴜꜱᴛ ᴀʙᴏᴜᴛ ᴡʜᴀᴛ ʏᴏᴜ ᴇᴀᴛ — ʏᴏᴜʀ ɢᴇɴᴇꜱ ᴘʟᴀʏ ᴀ ʜᴜɢᴇ ʀᴏʟᴇ ᴛᴏᴏ 🧬Research has identified 5 genes that di...
01/06/2026

ʏᴏᴜʀ ᴍᴇᴛᴀʙᴏʟɪꜱᴍ ɪꜱɴ'ᴛ ᴊᴜꜱᴛ ᴀʙᴏᴜᴛ ᴡʜᴀᴛ ʏᴏᴜ ᴇᴀᴛ — ʏᴏᴜʀ ɢᴇɴᴇꜱ ᴘʟᴀʏ ᴀ ʜᴜɢᴇ ʀᴏʟᴇ ᴛᴏᴏ 🧬

Research has identified 5 genes that directly shape how your body handles fat, cholesterol, hunger and blood sugar:

FUT2 — Specific variants raise triglycerides by nearly 26 mg/dL and lower HDL by 5.7 mg/dL compared to the protective variant, independent of diet (PMID: 36263525).

APOE — The ε4 variant is linked to a 26–42% higher coronary heart disease risk. It determines how efficiently fat is cleared from your bloodstream after meals.

FTO — Carriers of the rs9939609 risk variant are 31% more likely to develop obesity, with the gene impairing the brain's ability to signal fullness after eating.

PPARG — The master regulator of fat cell creation. The Pro12 variant is associated with a 40% higher risk of type 2 diabetes (PMID: 16401314).

TCF7L2 — Carriers of the rs7903146 risk variant show a 30% reduction in GLP-1 response (PMID: 19934000) — the same pathway Ozempic and Mounjaro are built to activate. If you've ever wondered why those drugs work better for some people than others, this gene is part of the answer.

Want to find out how these might be affecting you personally?

Head over to my Instagram .tzanis and DM me "Genes" — let's talk! 👇

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