02/11/2026
POLYNUCLEOTIDES. Let’s talk evidence, not hype. 👀
Apparently, every polynucleotide is now the best on the market.
Interesting. Because the science is a little more complicated than Instagram makes it look. 😂
Plinest. PolyPhil. Rejuran. Lumi Eyes. Luxia. Nucleofill. Vitaran. Ameela.
Different products. Different formulations. Plenty of claims.
But what does the evidence actually tell us?
Research into polynucleotides is encouraging, but study designs, formulations and treatment protocols vary.
Evidence for polynucleotides generally doesn’t automatically establish the effectiveness or superiority of every individual brand.
And more milligrams don’t necessarily mean better results.
I use Plinest and Croma PolyPhil following consideration of the available evidence, product quality and individual patient needs. Rejuran is another established product family I take seriously.
That doesn’t mean I’m claiming they’re universally superior.
All these years in nursing has taught me that knowing how to inject is one skill. Knowing WHY you’re choosing a treatment is another.
Because patients deserve more than a fashionable product name.
They deserve someone who can explain the reasoning behind their treatment.
Practitioners: How do you choose your polynucleotides? Let’s discuss. 👇
Patients: Not sure which skin treatment is right for you? That’s exactly what a proper consultation is for.
Rebeca Lydiatt RN
Nurse Independent Prescriber | Clinical Educator
Future Proof Medical